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Tbio
ZBTB7B
Zinc finger and BTB domain-containing protein 7B

Protein Summary
Description
Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, act ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292176
  • ENSP00000292176
  • ENSG00000160685
  • ENST00000368426
  • ENSP00000357411
  • ENST00000417934
  • ENSP00000406286
  • ENST00000535420
  • ENSP00000438647

Symbol
  • ZBTB15
  • ZFP67
  • ZNF857B
  • CKROX
  • THPOK
  • ZFP67
  • ZBTB15
  • ZFP-67
  • c-KROX
  • hcKROX
  • ZNF857B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
virus perturbation
0.88
protein domain
0.85
transcription factor
0.85
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.94   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.94   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  1
Score:  0.255
Data Source:  BioPlex,STRINGDB
CDCP1
Tbio
Novelty:  0.01385067
Score:  0.919
Data Source:  STRINGDB
RUNX3
Tbio
Family:  TF
Novelty:  0.00144472
Score:  0.874
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.873
Data Source:  STRINGDB
IMP4
Tdark
Novelty:  9.64444444
Score:  0.686
Data Source:  STRINGDB
GZMB
Tchem
Family:  Enzyme
Novelty:  0.00052869
Score:  0.685
Data Source:  STRINGDB
CD4
Tclin
Novelty:  0.00001217
Score:  0.652
Data Source:  STRINGDB
CD8A
Tbio
Novelty:  0.00002519
Score:  0.63
Data Source:  STRINGDB
ITK
Tclin
Family:  Kinase
Novelty:  0.00054195
Score:  0.611
Data Source:  STRINGDB
TBX21
Tbio
Family:  TF
Novelty:  0.0009971
Score:  0.593
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
Name
Explore in Pharos
Explore in Source
Ectoderm Differentiation
Ectoderm Differentiation
Ectoderm Differentiation
Ectoderm Differentiation
Ectoderm Differentiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (47)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
6
23
97.3
appendicular lean mass
3
4
5
96
serum gamma-glutamyl transferase measurement
3
5
5
95.7
eosinophil count
5
2
5
92.3
birth weight
4
2
4
91.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
23
97.3
appendicular lean mass
5
96
serum gamma-glutamyl transferase measurement
5
95.7
eosinophil count
5
92.3
birth weight
4
91.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 7B
VGNC:8127
457353
Macaque
zinc finger and BTB domain containing 7B
719006
Mouse
MGI:102755
22724
Rat
RGD:1305963
295248
Dog
zinc finger and BTB domain containing 7B
VGNC:48545
490437
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 7B
Macaque
zinc finger and BTB domain containing 7B
Mouse
Rat
Dog
zinc finger and BTB domain containing 7B
Publication Statistics
PubMed Score 68.94
PubMed score by year
PubTator Score 34.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title