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Tbio
ZBTB38
Zinc finger and BTB domain-containing protein 38

Protein Summary
Description
Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321464
  • ENSP00000372635
  • ENSG00000177311
  • ENST00000441582
  • ENSP00000406955
  • ENST00000514251
  • ENSP00000426387
  • ENST00000637056
  • ENSP00000490041

Symbol
  • CIBZ
  • ZNF921
  • PPP1R171
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.85
protein domain
0.85
ligand (protein) perturbation
0.83
virus perturbation
0.72
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.1   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.1   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.999994366
p_ni:  0.000005634
Score:  0.164
Data Source:  BioPlex,STRINGDB
LRR1
Tbio
Novelty:  0.02407468
p_int:  0.999989725
p_ni:  0.000010261
p_wrong:  1.4e-8
Score:  0.199
Data Source:  BioPlex,STRINGDB
TRIM26
Tbio
Novelty:  0.07177119
p_int:  0.994932486
p_ni:  0.005067502
p_wrong:  1.3e-8
Score:  0.184
Data Source:  BioPlex,STRINGDB
IPO7
Tbio
Novelty:  0.01319011
p_int:  0.963050573
p_ni:  0.036949427
Score:  0.188
Data Source:  BioPlex,STRINGDB
ZCCHC17
Tbio
Novelty:  0.06999007
p_int:  0.955463788
p_ni:  0.044536212
Score:  0.245
Data Source:  BioPlex,STRINGDB
NEMF
Tbio
Novelty:  0.05052246
p_int:  0.90294143
p_ni:  0.097058569
Score:  0.231
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.897992642
p_ni:  0.102007358
Data Source:  BioPlex
MRPS35
Tdark
Novelty:  6.44240335
p_int:  0.872465167
p_ni:  0.127534832
Data Source:  BioPlex
HIST2H2AB
Tbio
Novelty:  0.06772132
p_int:  0.856112531
p_ni:  0.143887424
p_wrong:  4.5e-8
Data Source:  BioPlex
YTHDC2
Tbio
Family:  Enzyme
Novelty:  0.05211009
p_int:  0.848087051
p_ni:  0.151912949
Score:  0.197
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (62)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
15
8
17
7.4
99.4
BMI-adjusted hip circumference
3
13
19
98.8
hair color
2
2
0
1.1
93.5
myeloid white cell count
3
3
4
93
BMI-adjusted waist circumference
7
13
25
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
17
7.4
99.4
BMI-adjusted hip circumference
19
98.8
hair color
0
1.1
93.5
myeloid white cell count
4
93
BMI-adjusted waist circumference
25
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 38
VGNC:12245
460740
Macaque
zinc finger and BTB domain containing 38
715184
Mouse
MGI:2442866
245007
Rat
RGD:1310136
315936
Dog
zinc finger and BTB domain containing 38
VGNC:48534
477096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 38
Macaque
zinc finger and BTB domain containing 38
Mouse
Rat
Dog
zinc finger and BTB domain containing 38
Publication Statistics
PubMed Score 23.10
PubMed score by year
PubTator Score 13.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title