Tdark ZBTB34 Zinc finger and BTB domain-containing protein 34

Protein Summary

Description

May be a transcriptional repressor.

Uniprot Accession IDs

• Q8NCN2
• Q38IA7
• Q5VYE9

Gene Name

• ZBTB34

Ensembl ID

• ENST00000373452
• ENSP00000362551
• ENSG00000177125

Symbol

• KIAA1993
• ZNF918

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
microRNA	0.75
transcription factor binding site profile	0.66
histone modification site profile	0.62
kinase perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.49   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 43   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.49   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (33)

Explore Interacting Targets

1 – 10 of 33

• See Interactions on String-DB

FOXN3

Tbio

Family:  TF

Novelty:  0.02908033

p_int:  0.999994942

p_ni:  0.000002318

p_wrong:  0.00000274

Score:  0.378

Data Source:  BioPlex,STRINGDB

TH

Tclin

Family:  Enzyme

Novelty:  0.00025719

p_int:  0.999969092

p_ni:  8.32e-7

p_wrong:  0.000030075

Score:  0.199

Data Source:  BioPlex,STRINGDB

ZBTB24

Tbio

Family:  TF

Novelty:  0.041401

p_int:  0.999888971

p_ni:  0.000101483

p_wrong:  0.000009546

Data Source:  BioPlex

ABTB2

Tdark

Novelty:  0.45729157

p_int:  0.999728486

p_ni:  0.000120382

p_wrong:  0.000151132

Data Source:  BioPlex

L3MBTL1

Tchem

Family:  TF; Epigenetic

Novelty:  0.02321712

p_int:  0.988607922

p_ni:  0.000457322

p_wrong:  0.010934756

Score:  0.227

Data Source:  BioPlex,STRINGDB

KLHL22

Tbio

Novelty:  0.24456252

p_int:  0.949591324

p_ni:  0.000057113

p_wrong:  0.050351562

Score:  0.188

Data Source:  BioPlex,STRINGDB

POLR1B

Tbio

Family:  Enzyme

Novelty:  0.06955307

Score:  0.72

Data Source:  STRINGDB

TASP1

Tchem

Family:  Enzyme

Novelty:  0.03454675

Score:  0.704

Data Source:  STRINGDB

LGALS4

Tchem

Novelty:  0.00021923

Score:  0.649

Data Source:  STRINGDB

RHBDD2

Tbio

Family:  Enzyme

Novelty:  0.17415558

Score:  0.591

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

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1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	1	1	0	1.1	35
alcohol consumption measurement	EFO_0007878	2	1	2		31.4
alcohol use disorder measurement	EFO_0009458	1	1	1		17.8
mathematical ability	EFO_0004875	2	1	2		4.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	0	1.1	35
alcohol consumption measurement	EFO_0007878	2		31.4
alcohol use disorder measurement	EFO_0009458	1		17.8
mathematical ability	EFO_0004875	2		4.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Repeat
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
alcohol use disorder measurement
mathematical ability
schizophrenia

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	zinc finger and BTB domain containing 34	MGI:2685195	241311
Rat	zinc finger and BTB domain containing 34	RGD:1596130	689174
Dog	zinc finger and BTB domain containing 34	VGNC:48532	491331
Horse	zinc finger and BTB domain containing 34	VGNC:25145	100070589
Cow	zinc finger and BTB domain containing 34	VGNC:37074	518084

Species	Name	OMA	EggNOG	Inparanoid
Mouse	zinc finger and BTB domain containing 34
Rat	zinc finger and BTB domain containing 34
Dog	zinc finger and BTB domain containing 34
Horse	zinc finger and BTB domain containing 34
Cow	zinc finger and BTB domain containing 34

Publication Statistics

PubMed Score 1.49

PubMed score by year

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PubTator Score 1.34

PubTator score by year

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Related Publications

Text Mined References (5)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title