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Tbio
ZBTB25
Zinc finger and BTB domain-containing protein 25

Protein Summary
Description
May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394715
  • ENSP00000378204
  • ENSG00000089775
  • ENST00000608382
  • ENSP00000476746

Symbol
  • C14orf51
  • KUP
  • ZNF46
  • KUP
  • ZNF46
  • C14orf51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.68
transcription factor perturbation
0.68
transcription factor
0.61
histone modification site profile
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.71   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.71   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.999888036
p_ni:  2.52e-7
p_wrong:  0.000111712
Score:  0.198
Data Source:  BioPlex,STRINGDB
ELP6
Tbio
Novelty:  0.01229878
p_int:  0.988770476
p_ni:  0.000001692
p_wrong:  0.011227832
Score:  0.534
Data Source:  BioPlex,STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.677
Data Source:  STRINGDB
WNK1
Tchem
Family:  Kinase
Novelty:  0.00270535
Score:  0.67
Data Source:  STRINGDB
TCFL5
Tbio
Family:  TF
Novelty:  0.00483499
Score:  0.606
Data Source:  STRINGDB
ZFP82
Tbio
Family:  TF
Novelty:  0.16236641
Score:  0.538
Data Source:  STRINGDB
ZNF16
Tbio
Family:  TF
Novelty:  0.18433365
Score:  0.538
Data Source:  STRINGDB
ZNF555
Tdark
Family:  TF
Novelty:  1.65285128
Score:  0.528
Data Source:  STRINGDB
ZNF696
Tdark
Family:  TF
Novelty:  3.49300122
Score:  0.505
Data Source:  STRINGDB
ZNF35
Tbio
Family:  TF
Novelty:  0.12382643
Score:  0.501
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
94.6
lymphocyte percentage of leukocytes
2
2
2
88.9
neutrophil percentage of leukocytes
1
1
1
71.2
self reported educational attainment
1
1
1
51.4
heel bone mineral density
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
94.6
lymphocyte percentage of leukocytes
2
88.9
neutrophil percentage of leukocytes
1
71.2
self reported educational attainment
1
51.4
heel bone mineral density
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger and BTB domain containing 25
707380
Mouse
MGI:99197
109929
Rat
RGD:735076
314245
Dog
zinc finger and BTB domain containing 25
VGNC:48529
490730
Horse
zinc finger and BTB domain containing 25
VGNC:25141
100052189
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger and BTB domain containing 25
Mouse
Rat
Dog
zinc finger and BTB domain containing 25
Horse
zinc finger and BTB domain containing 25
Publication Statistics
PubMed Score 158.71
PubMed score by year
PubTator Score 16.03
PubTator score by year
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Related Publications
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PMID
Year
Title