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Tbio
ZBTB2
Zinc finger and BTB domain-containing protein 2

Protein Summary
Description
May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325144
  • ENSP00000323183
  • ENSG00000181472

Symbol
  • KIAA1483
  • ZNF437
  • ZNF437
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.77
histone modification site profile
0.72
virus perturbation
0.68
cell line
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.61   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.61   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
ELP6
Tbio
Novelty:  0.01229878
p_int:  0.999999886
p_ni:  1.13e-7
Score:  0.198
Data Source:  BioPlex,STRINGDB
RASSF8
Tbio
Novelty:  0.09245647
p_int:  0.999993256
p_ni:  0.000006744
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999975937
p_ni:  0.000008984
p_wrong:  0.000015078
Score:  0.488
Data Source:  BioPlex,STRINGDB
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.999974774
p_ni:  0.000003749
p_wrong:  0.000021477
Data Source:  BioPlex
ANGPTL2
Tbio
Novelty:  0.01134724
p_int:  0.999952408
p_ni:  0.000045683
p_wrong:  0.000001909
Score:  0.297
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999880172
p_ni:  0.000119786
p_wrong:  4.2e-8
Score:  0.315
Data Source:  BioPlex,STRINGDB
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.99984626
p_ni:  0.00015374
Score:  0.555
Data Source:  BioPlex,STRINGDB
MBD3L1
Tbio
Novelty:  0.11297566
p_int:  0.999575937
p_ni:  0.000394807
p_wrong:  0.000029256
Score:  0.712
Data Source:  BioPlex,STRINGDB
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.999272862
p_ni:  0.000697453
p_wrong:  0.000029686
Data Source:  BioPlex
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.998897199
p_ni:  0.001073279
p_wrong:  0.000029522
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
78.5
monocyte count
1
1
1
57.8
sex hormone-binding globulin measurement
2
1
2
55.2
neutrophil count
1
1
1
35
appendicular lean mass
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
78.5
monocyte count
1
57.8
sex hormone-binding globulin measurement
2
55.2
neutrophil count
1
35
appendicular lean mass
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 2
VGNC:7940
472162
Macaque
zinc finger and BTB domain containing 2
704782
Mouse
MGI:2685949
381990
Rat
RGD:1306621
308126
Dog
zinc finger and BTB domain containing 2
VGNC:54005
484036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 2
Macaque
zinc finger and BTB domain containing 2
Mouse
Rat
Dog
zinc finger and BTB domain containing 2
Publication Statistics
PubMed Score 11.61
PubMed score by year
PubTator Score 4.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title