Tbio ZBTB16 Zinc finger and BTB domain-containing protein 16

Protein Summary

Description

Acts as a transcriptional repressor (PubMed:24359566). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q05516
• Q8TAL4

Gene Name

• ZBTB16

Ensembl ID

• ENST00000335953
• ENSP00000338157
• ENSG00000109906
• ENST00000392996
• ENSP00000376721

Symbol

• PLZF
• ZNF145
• PLZF
• ZNF145

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
gene perturbation	0.96
hub protein	0.96
molecular function	0.96
PubMedID	0.86

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger And Btb Domain-containing Protein 16

Protein / ... / Krab Box Transcription Factor / Zinc Finger And Btb Domain-containing Protein 16

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Zinc Finger And Btb Domain-containing Protein 16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.17   (req: < 5)

Gene RIFs: 103   (req: <= 3)

Antibodies: 360   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.17   (req: >= 5)

Gene RIFs: 103   (req: > 3)

Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0