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Tbio
ZBTB16
Zinc finger and BTB domain-containing protein 16

Protein Summary
Description
Acts as a transcriptional repressor (PubMed:24359566). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335953
  • ENSP00000338157
  • ENSG00000109906
  • ENST00000392996
  • ENSP00000376721

Symbol
  • PLZF
  • ZNF145
  • PLZF
  • ZNF145
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
gene perturbation
0.96
hub protein
0.96
molecular function
0.96
PubMedID
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.53   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.53   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (445)
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.999942762
p_ni:  0.000003083
p_wrong:  0.000054155
Score:  0.319
Data Source:  BioPlex,STRINGDB
BTBD6
Tdark
Novelty:  0.24005804
Score:  0.966
Data Source:  STRINGDB
RARA
Tclin
Family:  NR
Novelty:  0.00080574
Score:  0.954
Data Source:  STRINGDB
BTBD1
Tbio
Novelty:  0.19772296
Score:  0.935
Data Source:  STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.932
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.932
Data Source:  STRINGDB
RNF213
Tbio
Family:  Enzyme
Novelty:  0.00588778
Score:  0.931
Data Source:  STRINGDB
TRIM36
Tbio
Family:  Enzyme
Novelty:  0.06724803
Score:  0.931
Data Source:  STRINGDB
UBE2M
Tchem
Novelty:  0.02353106
Score:  0.924
Data Source:  STRINGDB
FBXO15
Tbio
Novelty:  0.08562497
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 5 of 5
CDK4
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  1
VEGFB
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
CDK6
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  1
VEGFA
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
PGF
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  1
Pathways (14)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (46)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
6
97.9
neutrophil count
3
4
5
96.5
monocyte percentage of leukocytes
2
3
4
95.9
platelet count
2
3
5
95.8
myeloid white cell count
2
3
3
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
97.9
neutrophil count
5
96.5
monocyte percentage of leukocytes
4
95.9
platelet count
5
95.8
myeloid white cell count
3
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 16
VGNC:12778
100614588
Macaque
zinc finger and BTB domain containing 16
695064
Mouse
MGI:103222
235320
Rat
RGD:727921
353227
Dog
zinc finger and BTB domain containing 16
VGNC:48524
489398
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 16
Macaque
zinc finger and BTB domain containing 16
Mouse
Rat
Dog
zinc finger and BTB domain containing 16
Publication Statistics
PubMed Score 325.53
PubMed score by year
PubTator Score 198.03
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title