Tbio ZBP1 Z-DNA-binding protein 1

Protein Summary

Description

Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9H171
• A2A2F7
• B3KVA1
• F5GYT1
• Q5JY39
• Q9BYW4

Gene Name

• ZBP1

Ensembl ID

• ENST00000371173
• ENSP00000360215
• ENSG00000124256
• ENST00000395822
• ENSP00000379167
• ENST00000541799
• ENSP00000440552

Symbol

• C20orf183
• DLM1
• DAI
• DLM1
• DLM-1
• C20orf183

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
kinase perturbation	0.66
gene perturbation	0.63
molecular function	0.6
disease	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.97   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.97   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0