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Tdark
ZBBX
Zinc finger B-box domain-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307529
  • ENSP00000305065
  • ENSG00000169064
  • ENST00000392764
  • ENSP00000376517
  • ENST00000392766
  • ENSP00000376519
  • ENST00000392767
  • ENSP00000376520
  • ENST00000455345
  • ENSP00000390232
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.65
cell line
0.63
histone modification site profile
0.59
cell type or tissue
0.58
phenotype
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
FAT3
Tbio
Novelty:  0.03661008
p_int:  0.999857475
p_ni:  0.000142525
Score:  0.162
Data Source:  BioPlex,STRINGDB
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.998477349
p_ni:  0.001522651
Data Source:  BioPlex
KIAA0232
Tdark
Novelty:  2.37569744
p_int:  0.998387697
p_ni:  0.001612303
Data Source:  BioPlex
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.994436557
p_ni:  0.005563442
Data Source:  BioPlex
SORL1
Tbio
Novelty:  0.00380895
p_int:  0.990869579
p_ni:  0.009130421
Data Source:  BioPlex
TBC1D17
Tdark
Novelty:  0.64376132
p_int:  0.987858934
p_ni:  0.00635187
p_wrong:  0.005789196
Score:  0.189
Data Source:  BioPlex,STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.986725472
p_ni:  0.013274512
p_wrong:  1.6e-8
Data Source:  BioPlex
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.974764069
p_ni:  0.025235402
p_wrong:  5.29e-7
Score:  0.219
Data Source:  BioPlex,STRINGDB
CELSR2
Tbio
Family:  GPCR
Novelty:  0.02657319
p_int:  0.959876118
p_ni:  0.040123882
Data Source:  BioPlex
HECTD3
Tdark
Family:  Enzyme
Novelty:  2.20874654
p_int:  0.942608303
p_ni:  0.057391697
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diet measurement
4
3
4
67.1
high density lipoprotein cholesterol measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diet measurement
4
67.1
high density lipoprotein cholesterol measurement
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger B-box domain containing
VGNC:8017
743482
Macaque
zinc finger B-box domain containing
700091
Mouse
MGI:2674085
213234
Rat
RGD:1308632
361964
Dog
zinc finger B-box domain containing
VGNC:48512
100855956
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger B-box domain containing
Macaque
zinc finger B-box domain containing
Mouse
Rat
Dog
zinc finger B-box domain containing
Publication Statistics
PubMed Score 0.52
PubMed score by year
PubTator Score 0.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title