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Tchem
ZAP70
Tyrosine-protein kinase ZAP-70

Protein Summary
Description
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, ad ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264972
  • ENSP00000264972
  • ENSG00000115085
  • ENST00000451498
  • ENSP00000400475

Symbol
  • SRK
  • SRK
  • STD
  • TZK
  • STCD
  • IMD48
  • ADMIO2
  • ZAP-70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
biological term
0.97
molecular function
0.96
hub protein
0.95
biological process
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 901.2   (req: < 5)
Gene RIFs: 190   (req: <= 3)
Antibodies: 2035   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 901.2   (req: >= 5)
Gene RIFs: 190   (req: > 3)
Antibodies: 2035   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1