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Tbio
YY1AP1
YY1-associated protein 1

Protein Summary
Description
Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295566
  • ENSP00000295566
  • ENSG00000163374
  • ENST00000311573
  • ENSP00000311138
  • ENST00000347088
  • ENSP00000316079
  • ENST00000355499
  • ENSP00000347686
  • ENST00000359205
  • ENSP00000352134
  • ENST00000361831
  • ENSP00000355298
  • ENST00000368330
  • ENSP00000357314
  • ENST00000368339
  • ENSP00000357323
  • ENST00000368340
  • ENSP00000357324
  • ENST00000404643
  • ENSP00000385390
  • ENST00000407221
  • ENSP00000385791

Symbol
  • HCCA2
  • YY1AP
  • GRNG
  • HCCA1
  • HCCA2
  • YY1AP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.69
transcription factor
0.64
tissue sample
0.63
cell type or tissue
0.61
tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.16   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.16   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
ZNF524
Tdark
Family:  TF
Novelty:  2.44930764
p_int:  0.999998381
p_ni:  0.000001618
p_wrong:  1e-9
Score:  0.319
Data Source:  BioPlex,STRINGDB
SS18L2
Tdark
Novelty:  1.37000973
p_int:  0.999996984
p_ni:  5.77e-7
p_wrong:  0.000002439
Score:  0.547
Data Source:  BioPlex,STRINGDB
CLEC3A
Tdark
Novelty:  0.21498836
p_int:  0.999945796
p_ni:  0.000054204
Score:  0.519
Data Source:  BioPlex,STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.999906062
p_ni:  0.000093935
p_wrong:  4e-9
Score:  0.519
Data Source:  BioPlex,STRINGDB
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.999845049
p_ni:  0.000154929
p_wrong:  2.2e-8
Data Source:  BioPlex
PRR20E
Tdark
p_int:  0.999651249
p_ni:  0.000344037
p_wrong:  0.000004714
Data Source:  BioPlex
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.999239256
p_ni:  0.000760057
p_wrong:  6.87e-7
Data Source:  BioPlex
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.999170287
p_ni:  0.000829573
p_wrong:  1.41e-7
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999148885
p_ni:  0.0005348
p_wrong:  0.000316315
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.999034462
p_ni:  0.000964962
p_wrong:  5.76e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Hippo-Yap signaling pathway
WikiPathways
Hippo-Merlin Signaling Dysregulation
WikiPathways
Envelope proteins and their potential roles in EDMD physiopathology
WikiPathways
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
WikiPathways
Pathways Regulating Hippo Signaling
Name
Explore in Pharos
Explore in Source
Hippo-Yap signaling pathway
Hippo-Merlin Signaling Dysregulation
Envelope proteins and their potential roles in EDMD physiopathology
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
Pathways Regulating Hippo Signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
1
1
1
74.8
serum urea measurement
1
2
2
62
serum gamma-glutamyl transferase measurement
1
1
1
53.7
cancer antigen 15.3 measurement
1
1
1
50.6
appendicular lean mass
1
2
2
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
1
74.8
serum urea measurement
2
62
serum gamma-glutamyl transferase measurement
1
53.7
cancer antigen 15.3 measurement
1
50.6
appendicular lean mass
2
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YY1 associated protein 1
VGNC:10878
457375
Macaque
GON-4-like protein
719288
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YY1 associated protein 1
Macaque
GON-4-like protein
Publication Statistics
PubMed Score 14.16
PubMed score by year
PubTator Score 9.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title