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Tbio
YY1
Transcriptional repressor protein YY1

Protein Summary
Description
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presenc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262238
  • ENSP00000262238
  • ENSG00000100811

Symbol
  • INO80S
  • DELTA
  • NF-E1
  • UCRBP
  • GADEVS
  • INO80S
  • YIN-YANG-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
1
disease perturbation
0.98
hub protein
0.98
transcription factor perturbation
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 917.97   (req: < 5)
Gene RIFs: 216   (req: <= 3)
Antibodies: 542   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 917.97   (req: >= 5)
Gene RIFs: 216   (req: > 3)
Antibodies: 542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (411)
INO80
Tbio
Family:  Enzyme
Novelty:  0.09412936
p_int:  0.999997748
p_ni:  0.000002252
Score:  0.966
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.999991071
p_ni:  0.000008929
Score:  0.957
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.999984247
p_ni:  0.000015728
p_wrong:  2.5e-8
Score:  0.979
Data Source:  BioPlex,STRINGDB
INO80C
Tdark
Novelty:  0.04242834
p_int:  0.99998191
p_ni:  0.00001809
Score:  0.932
Data Source:  BioPlex,STRINGDB
ADSSL1
Tbio
Family:  Enzyme
Novelty:  0.0511949
p_int:  0.999903392
p_ni:  0.000096603
p_wrong:  6e-9
Data Source:  BioPlex
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.999649159
p_ni:  0.00035083
p_wrong:  1.1e-8
Score:  0.959
Data Source:  BioPlex,STRINGDB
ID2
Tbio
Family:  TF
Novelty:  0.00256364
p_int:  0.981985099
p_ni:  0.011023875
p_wrong:  0.006991026
Score:  0.38
Data Source:  BioPlex,STRINGDB
TMEM150A
Tbio
Novelty:  0.12446897
p_int:  0.973999973
p_ni:  0.025998607
p_wrong:  0.00000142
Score:  0.295
Data Source:  BioPlex,STRINGDB
PPP1R3B
Tbio
Family:  Enzyme
Novelty:  0.0244434
p_int:  0.969535165
p_ni:  0.02412338
p_wrong:  0.006341455
Score:  0.259
Data Source:  BioPlex,STRINGDB
TRPV5
Tchem
Family:  IC
Novelty:  0.0055156
p_int:  0.954340886
p_ni:  0.045293936
p_wrong:  0.000365178
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (57)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (45)
Find Similar Targets
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
AgBase
Inferred from Mutant Phenotype (IMP)
AgBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
90.9
testosterone measurement
3
3
3
74
age at menarche
1
1
1
62.1
apolipoprotein A 1 measurement
1
1
1
59.9
pulse pressure measurement
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
90.9
testosterone measurement
3
74
age at menarche
1
62.1
apolipoprotein A 1 measurement
1
59.9
pulse pressure measurement
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YY1 transcription factor
VGNC:12433
453159
Macaque
YY1 transcription factor
717370
Mouse
MGI:99150
22632
Rat
RGD:3982
24919
Dog
YY1 transcription factor
VGNC:51693
611171
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YY1 transcription factor
Macaque
YY1 transcription factor
Mouse
Rat
Dog
YY1 transcription factor
Publication Statistics
PubMed Score 917.97
PubMed score by year
PubTator Score 517.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title