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Tchem
YWHAZ
14-3-3 protein zeta/delta

Protein Summary
Description
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353245
  • ENSP00000309503
  • ENSG00000164924
  • ENST00000395951
  • ENSP00000379281
  • ENST00000395953
  • ENSP00000379283
  • ENST00000395956
  • ENSP00000379286
  • ENST00000395957
  • ENSP00000379287
  • ENST00000395958
  • ENSP00000379288
  • ENST00000419477
  • ENSP00000395114
  • ENST00000457309
  • ENSP00000398599
  • ENST00000522542
  • ENSP00000430072

Symbol
  • HEL4
  • YWHAD
  • KCIP-1
  • HEL-S-3
  • HEL-S-93
  • 14-3-3-zeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
co-expressed gene
0.99
kinase
0.99


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 559.53   (req: < 5)
Gene RIFs: 144   (req: <= 3)
Antibodies: 918   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 559.53   (req: >= 5)
Gene RIFs: 144   (req: > 3)
Antibodies: 918   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (390)
FAM86C1
Tdark
Family:  Enzyme
Novelty:  1.61781609
p_int:  0.999982457
p_ni:  0.000017543
Data Source:  BioPlex
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.999978354
p_ni:  0.000021646
Score:  0.978
Data Source:  BioPlex,STRINGDB
SMTNL2
Tdark
Novelty:  0.33805653
p_int:  0.999895446
p_ni:  0.000104554
Score:  0.183
Data Source:  BioPlex,STRINGDB
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.999314326
p_ni:  0.000685674
Score:  0.664
Data Source:  BioPlex,STRINGDB
CGN
Tbio
Novelty:  0.01097394
p_int:  0.998786884
p_ni:  0.001213116
Data Source:  BioPlex
SPATA13
Tbio
Novelty:  0.19610601
p_int:  0.997843189
p_ni:  0.002156811
Score:  0.338
Data Source:  BioPlex,STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.997801624
p_ni:  0.002198376
Data Source:  BioPlex
SAMD4A
Tbio
Novelty:  0.04440962
p_int:  0.996991861
p_ni:  0.003008139
Score:  0.165
Data Source:  BioPlex,STRINGDB
PLEKHG5
Tbio
Novelty:  0.01182841
p_int:  0.993410715
p_ni:  0.006589285
Score:  0.227
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.991874996
p_ni:  0.008125004
Data Source:  BioPlex
Pathways (98)
Activation of BAD and translocation to mitochondria (R-HSA-111447)

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Find Similar Targets
Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Adaptive Immune System
Reactome
Apoptosis
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Adaptive Immune System
Apoptosis
Cell Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
SynGO-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
2
2
75.2
body mass index
2
2
2
55.4
interleukin 10 measurement
1
1
1
44.4
reticulocyte count
1
1
1
7.4
chronotype measurement
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
75.2
body mass index
2
55.4
interleukin 10 measurement
1
44.4
reticulocyte count
1
7.4
chronotype measurement
1
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
709723
Mouse
MGI:109484
22631
Rat
RGD:3980
25578
Dog
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
475864
Horse
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
VGNC:25121
100056060
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Mouse
Rat
Dog
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Horse
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Publication Statistics
PubMed Score 559.53
PubMed score by year
PubTator Score 148.27
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title