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Tchem
YWHAH
14-3-3 protein eta

Protein Summary
Description
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248975
  • ENSP00000248975
  • ENSG00000128245

Symbol
  • YWHA1
  • YWHA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
biological process
0.95
kinase perturbation
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.65   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.65   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (223)
FAM86C1
Tdark
Family:  Enzyme
Novelty:  1.61781609
p_int:  0.99838002
p_ni:  0.00161998
Data Source:  BioPlex
SMTNL2
Tdark
Novelty:  0.33805653
p_int:  0.997100407
p_ni:  0.002899593
Score:  0.257
Data Source:  BioPlex,STRINGDB
LNP1
Tdark
Novelty:  0.00457285
p_int:  0.981245747
p_ni:  0.018754253
Data Source:  BioPlex
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.965409562
p_ni:  0.034590438
Score:  0.219
Data Source:  BioPlex,STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.961179982
p_ni:  0.038820018
Score:  0.956
Data Source:  BioPlex,STRINGDB
CGN
Tbio
Novelty:  0.01097394
p_int:  0.956677909
p_ni:  0.043322091
Score:  0.588
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.956505194
p_ni:  0.043494806
Data Source:  BioPlex
SPATA13
Tbio
Novelty:  0.19610601
p_int:  0.93420564
p_ni:  0.06579436
Score:  0.374
Data Source:  BioPlex,STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.930919254
p_ni:  0.069080746
Data Source:  BioPlex
SAMD4A
Tbio
Novelty:  0.04440962
p_int:  0.925524414
p_ni:  0.074475586
Score:  0.169
Data Source:  BioPlex,STRINGDB
Pathways (61)
Activation of BAD and translocation to mitochondria (R-HSA-111447)

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Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Apoptosis
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Apoptosis
Cell Cycle
Cell Cycle Checkpoints
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.8
59
HbA1c measurement
1
1
1
58.4
1,5 anhydroglucitol measurement
1
1
0
7.2
56.6
monocyte percentage of leukocytes
1
1
1
55.2
2
1
1
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
59
HbA1c measurement
1
58.4
1,5 anhydroglucitol measurement
0
7.2
56.6
monocyte percentage of leukocytes
1
55.2
1
1.1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
VGNC:10128
458778
Macaque
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
717016
Mouse
MGI:109194
22629
Rat
RGD:3978
25576
Dog
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
VGNC:52975
100687866
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Macaque
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Mouse
Rat
Dog
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Publication Statistics
PubMed Score 109.65
PubMed score by year
PubTator Score 31.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title