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Tchem
YWHAG
14-3-3 protein gamma

Protein Summary
Description
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307630
  • ENSP00000306330
  • ENSG00000170027

Symbol
  • EIEE56
  • PPP1R170
  • 14-3-3GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
small molecule perturbation
1
transcription factor perturbation
0.99
transcription factor binding site profile
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.34   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 494   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.34   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 494   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (358)
SMTNL2
Tdark
Novelty:  0.33805653
p_int:  0.999570046
p_ni:  0.000429954
Score:  0.223
Data Source:  BioPlex,STRINGDB
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.999127133
p_ni:  0.000872867
Score:  0.674
Data Source:  BioPlex,STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.996036294
p_ni:  0.003963706
Score:  0.954
Data Source:  BioPlex,STRINGDB
FAM86C1
Tdark
Family:  Enzyme
Novelty:  1.61781609
p_int:  0.994800497
p_ni:  0.005199503
Data Source:  BioPlex
LNP1
Tdark
Novelty:  0.00457285
p_int:  0.992534034
p_ni:  0.007465966
Data Source:  BioPlex
SPATA13
Tbio
Novelty:  0.19610601
p_int:  0.99241739
p_ni:  0.00758261
Score:  0.338
Data Source:  BioPlex,STRINGDB
TESPA1
Tbio
Novelty:  0.12779533
p_int:  0.98668077
p_ni:  0.01331923
Score:  0.211
Data Source:  BioPlex,STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.981903664
p_ni:  0.018096336
Data Source:  BioPlex
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.979902494
p_ni:  0.020097506
Data Source:  BioPlex
TFEB
Tbio
Family:  TF
Novelty:  0.00248413
p_int:  0.971711237
p_ni:  0.028288763
Score:  0.267
Data Source:  BioPlex,STRINGDB
Pathways (80)
AURKA Activation by TPX2 (R-HSA-8854518)

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Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Apoptosis
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Anchoring of the basal body to the plasma membrane
Apoptosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
77.1
heat shock 27 kDa protein measurement
1
1
1
51.7
self reported educational attainment
1
1
1
44.2
triglyceride measurement
1
1
1
40.7
apolipoprotein B measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
77.1
heat shock 27 kDa protein measurement
1
51.7
self reported educational attainment
1
44.2
triglyceride measurement
1
40.7
apolipoprotein B measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
VGNC:8791
463489
Macaque
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
715517
Mouse
MGI:108109
22628
Rat
RGD:62002
56010
Dog
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
VGNC:48509
489818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Macaque
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Mouse
Rat
Dog
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Publication Statistics
PubMed Score 131.34
PubMed score by year
PubTator Score 41.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title