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Tbio
YWHAE
14-3-3 protein epsilon

Protein Summary
Description
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript vari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264335
  • ENSP00000264335
  • ENSG00000108953
  • ENST00000571732
  • ENSP00000461762
  • ENST00000616643
  • ENSP00000481059
  • ENSG00000274474
  • ENST00000627231
  • ENSP00000487356

Symbol
  • MDS
  • HEL2
  • MDCR
  • KCIP-1
  • 14-3-3E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
protein complex
0.99
virus perturbation
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.59   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 442   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.59   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 442   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (442)
LNP1
Tdark
Novelty:  0.00457285
p_int:  0.999846418
p_ni:  0.000153582
Data Source:  BioPlex
FAM86C1
Tdark
Family:  Enzyme
Novelty:  1.61781609
p_int:  0.998646539
p_ni:  0.001353461
Data Source:  BioPlex
SMTNL2
Tdark
Novelty:  0.33805653
p_int:  0.998069552
p_ni:  0.001930448
Score:  0.229
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.993837537
p_ni:  0.006162463
Data Source:  BioPlex
PLEKHG5
Tbio
Novelty:  0.01182841
p_int:  0.993595594
p_ni:  0.006404406
Score:  0.272
Data Source:  BioPlex,STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.992660065
p_ni:  0.007339935
Score:  0.973
Data Source:  BioPlex,STRINGDB
SAMD4A
Tbio
Novelty:  0.04440962
p_int:  0.992584548
p_ni:  0.007415452
Score:  0.307
Data Source:  BioPlex,STRINGDB
SPATA13
Tbio
Novelty:  0.19610601
p_int:  0.989884086
p_ni:  0.010115914
Score:  0.357
Data Source:  BioPlex,STRINGDB
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.98840122
p_ni:  0.01159878
Score:  0.204
Data Source:  BioPlex,STRINGDB
CGN
Tbio
Novelty:  0.01097394
p_int:  0.985355372
p_ni:  0.014644628
Data Source:  BioPlex
Pathways (100)
AURKA Activation by TPX2 (R-HSA-8854518)

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Find Similar Targets
Items per page:
1 – 5 of 52
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Apoptosis
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Anchoring of the basal body to the plasma membrane
Apoptosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
Find Similar Targets
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SynGO-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (50)
Items per page:
1 – 5 of 50
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
3
3
92.1
mean platelet volume
2
3
3
92.1
lymphocyte percentage of leukocytes
2
3
3
89.6
lymphocyte percentage of leukocytes
2
3
3
89.6
neutrophil count
3
2
3
80.4
Items per page:
1 – 5 of 50
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
92.1
mean platelet volume
3
92.1
lymphocyte percentage of leukocytes
3
89.6
lymphocyte percentage of leukocytes
3
89.6
neutrophil count
3
80.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
VGNC:14225
454409
Mouse
MGI:894689
22627
Rat
RGD:62000
29753
Horse
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
VGNC:25118
100059962
Cow
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
VGNC:37045
282125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Mouse
Rat
Horse
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Cow
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Publication Statistics
PubMed Score 257.59
PubMed score by year
PubTator Score 108.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title