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Tbio
YTHDF3
YTH domain-containing family protein 3

Protein Summary
Description
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs and promotes RNA translation efficiency (PubMed:28106072, PubMed:28106076, PubMed:28281539). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28106076, PubMed:28281539). Shares m6A-containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (PubMed:28106072, PubMed:28106076). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRNAs and interacting with 40S and 60S ribosome subunits (PubMed:28106072, PubMed:28106076). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs) and promotes the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000539294
  • ENSP00000473496
  • ENSG00000185728
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
virus perturbation
0.76
transcription factor binding site profile
0.75
histone modification site profile
0.72
cell line
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.32   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.32   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
YTHDF1
Tbio
Novelty:  0.02063275
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.354
Data Source:  BioPlex,STRINGDB
METTL3
Tbio
Family:  Enzyme
Novelty:  0.00420954
Score:  0.775
Data Source:  STRINGDB
ALKBH5
Tchem
Family:  Enzyme
Novelty:  0.01158189
Score:  0.769
Data Source:  STRINGDB
WTAP
Tbio
Novelty:  0.01491546
Score:  0.745
Data Source:  STRINGDB
METTL14
Tbio
Family:  Enzyme
Novelty:  0.01377112
Score:  0.742
Data Source:  STRINGDB
VPS13B
Tbio
Novelty:  0.02154769
Score:  0.687
Data Source:  STRINGDB
PMFBP1
Tbio
Novelty:  0.25081073
Score:  0.659
Data Source:  STRINGDB
PPP1R35
Tdark
Family:  Enzyme
Novelty:  0.47022173
Score:  0.64
Data Source:  STRINGDB
VIRMA
Tbio
Novelty:  0.05400878
Score:  0.627
Data Source:  STRINGDB
ZNF609
Tdark
Novelty:  0.06635612
Score:  0.61
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
50
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
50
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1918850
229096
Rat
RGD:1305234
361920
Dog
YTH N6-methyladenosine RNA binding protein 3
VGNC:48507
486970
Cow
YTH N6-methyladenosine RNA binding protein 3
VGNC:37043
519708
Xenopus
YTH N6-methyladenosine RNA binding protein 3
XB-GENE-5752937
100145519
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
YTH N6-methyladenosine RNA binding protein 3
Cow
YTH N6-methyladenosine RNA binding protein 3
Xenopus
YTH N6-methyladenosine RNA binding protein 3
Publication Statistics
PubMed Score 43.32
PubMed score by year
PubTator Score 3.65
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title