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Tbio
YTHDF1
YTH domain-containing family protein 1

Protein Summary
Description
Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370339
  • ENSP00000359364
  • ENSG00000149658

Symbol
  • C20orf21
  • C20orf21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.91
virus perturbation
0.88
transcription factor binding site profile
0.8
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.14   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.14   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
YTHDF3
Tbio
Novelty:  0.05305719
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.354
Data Source:  BioPlex,STRINGDB
TUT1
Tbio
Family:  Enzyme
Novelty:  0.01436913
p_int:  0.999799041
p_ni:  0.000200959
Score:  0.163
Data Source:  BioPlex,STRINGDB
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.996934873
p_ni:  0.003065126
p_wrong:  1e-9
Data Source:  BioPlex
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
p_int:  0.994946136
p_ni:  0.005053862
p_wrong:  2e-9
Data Source:  BioPlex
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.994419767
p_ni:  0.005580233
Data Source:  BioPlex
ST8SIA3
Tbio
Family:  Enzyme
Novelty:  0.05984127
p_int:  0.990972766
p_ni:  0.009027234
Data Source:  BioPlex
PIP
Tbio
Novelty:  0.00208509
p_int:  0.989678696
p_ni:  0.010321301
p_wrong:  2e-9
Data Source:  BioPlex
CDIPT
Tbio
Family:  Enzyme
Novelty:  0.00560887
p_int:  0.989615771
p_ni:  0.010384229
Data Source:  BioPlex
PLPPR2
Tdark
Family:  Enzyme
Novelty:  1.03318406
p_int:  0.983499656
p_ni:  0.016500344
Data Source:  BioPlex
SLC25A11
Tbio
Family:  Transporter
Novelty:  0.06125899
p_int:  0.981714277
p_ni:  0.018285723
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YTH N6-methyladenosine RNA binding protein 1
VGNC:10062
470035
Macaque
YTH N6-methyladenosine RNA binding protein 1
697816
Mouse
MGI:1917431
228994
Rat
RGD:1308932
296467
Dog
YTH N6-methyladenosine RNA binding protein 1
VGNC:48505
485968
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YTH N6-methyladenosine RNA binding protein 1
Macaque
YTH N6-methyladenosine RNA binding protein 1
Mouse
Rat
Dog
YTH N6-methyladenosine RNA binding protein 1
Publication Statistics
PubMed Score 71.14
PubMed score by year
PubTator Score 5.04
PubTator score by year
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Related Publications
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PMID
Year
Title