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Tbio
YTHDC1
YTH domain-containing protein 1

Protein Summary
Description
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alter ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344157
  • ENSP00000339245
  • ENSG00000083896
  • ENST00000355665
  • ENSP00000347888
  • ENST00000613637
  • ENSP00000484604
  • ENSG00000275272
  • ENST00000615500
  • ENSP00000479213

Symbol
  • KIAA1966
  • YT521
  • YT521
  • YT521-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase
0.9
virus perturbation
0.88
ligand (protein) perturbation
0.83
microRNA
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.99   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.99   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.999978451
p_ni:  0.000021549
p_wrong:  1e-9
Score:  0.288
Data Source:  BioPlex,STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.999771855
p_ni:  0.000228136
p_wrong:  9e-9
Score:  0.224
Data Source:  BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.999455736
p_ni:  0.000544214
p_wrong:  4.9e-8
Score:  0.192
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.999181411
p_ni:  0.000818586
p_wrong:  3e-9
Score:  0.415
Data Source:  BioPlex,STRINGDB
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.998972753
p_ni:  0.001027247
Score:  0.757
Data Source:  BioPlex,STRINGDB
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.995713167
p_ni:  0.004286833
Score:  0.277
Data Source:  BioPlex,STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.991854346
p_ni:  0.008145415
p_wrong:  2.39e-7
Score:  0.155
Data Source:  BioPlex,STRINGDB
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.987439268
p_ni:  0.012560614
p_wrong:  1.18e-7
Score:  0.798
Data Source:  BioPlex,STRINGDB
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.981208727
p_ni:  0.018791248
p_wrong:  2.6e-8
Data Source:  BioPlex
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.976488693
p_ni:  0.023499323
p_wrong:  0.000011985
Score:  0.358
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
32.7
IGF-1 measurement
1
1
1
32.7
total cholesterol measurement
1
1
1
31.1
total cholesterol measurement
1
1
1
31.1
low density lipoprotein cholesterol measurement
1
1
1
17.6
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
32.7
IGF-1 measurement
1
32.7
total cholesterol measurement
1
31.1
total cholesterol measurement
1
31.1
low density lipoprotein cholesterol measurement
1
17.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YTH domain containing 1
VGNC:12940
461291
Macaque
YTH domain containing 1
709717
Mouse
MGI:2443713
231386
Rat
RGD:621706
170956
Dog
YTH domain containing 1
VGNC:48503
475161
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YTH domain containing 1
Macaque
YTH domain containing 1
Mouse
Rat
Dog
YTH domain containing 1
Publication Statistics
PubMed Score 76.99
PubMed score by year
PubTator Score 16.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title