You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
YPEL5
Protein yippee-like 5

Protein Summary
Description
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for normal cell proliferation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261353
  • ENSP00000261353
  • ENSG00000119801
  • ENST00000379519
  • ENSP00000368834
  • ENST00000379520
  • ENSP00000368835
  • ENST00000402003
  • ENSP00000383974
  • ENST00000402708
  • ENSP00000385278

Symbol
  • CGI-127
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
kinase perturbation
0.96
transcription factor binding site profile
0.9
virus perturbation
0.83
PubMedID
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.65   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.65   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.874193657
p_ni:  0.125806343
Score:  0.757
Data Source:  BioPlex,STRINGDB
GCG
Tchem
Novelty:  0.00004879
p_int:  0.831380988
p_ni:  0.168619012
Data Source:  BioPlex
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.79204365
p_ni:  0.20795635
Score:  0.887
Data Source:  BioPlex,STRINGDB
ARMC8
Tbio
Novelty:  0.06820746
Score:  0.966
Data Source:  STRINGDB
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
Score:  0.909
Data Source:  STRINGDB
LRG1
Tbio
Novelty:  0.00445522
Score:  0.908
Data Source:  STRINGDB
ALDOA
Tbio
Family:  Enzyme
Novelty:  0.00517474
Score:  0.906
Data Source:  STRINGDB
GOLGA7
Tbio
Novelty:  0.17108842
Score:  0.904
Data Source:  STRINGDB
LYZ
Tbio
Family:  Enzyme
Novelty:  0.00151342
Score:  0.904
Data Source:  STRINGDB
IDH1
Tclin
Family:  Enzyme
Novelty:  0.0004831
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
68.5
myeloid white cell count
1
1
1
49.5
refractive error measurement
1
1
1
45.2
leukocyte count
1
1
1
39.6
apolipoprotein A 1 measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
68.5
myeloid white cell count
1
49.5
refractive error measurement
1
45.2
leukocyte count
1
39.6
apolipoprotein A 1 measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
yippee like 5
VGNC:427
459128
Macaque
yippee like 5
704532
Mouse
MGI:1916937
383295
Rat
RGD:1309657
298792
Dog
yippee like 5
VGNC:48501
475714
Species
Name
OMA
EggNOG
Inparanoid
Chimp
yippee like 5
Macaque
yippee like 5
Mouse
Rat
Dog
yippee like 5
Publication Statistics
PubMed Score 4.65
PubMed score by year
PubTator Score 2.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title