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Tdark
YLPM1
YLP motif-containing protein 1

Protein Summary
Description
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325680
  • ENSP00000324463
  • ENSG00000119596

Symbol
  • C14orf170
  • ZAP3
  • ZAP3
  • ZAP113
  • PPP1R169
  • C14orf170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
interacting protein
0.96
virus perturbation
0.94
transcription factor binding site profile
0.77
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.8   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.8   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999237
p_ni:  7.63e-7
Score:  0.619
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.99999436
p_ni:  0.00000564
Score:  0.619
Data Source:  BioPlex,STRINGDB
MAGEE1
Tbio
Novelty:  0.10759081
p_int:  0.999963978
p_ni:  0.000036022
Score:  0.187
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.999925592
p_ni:  0.000074408
Data Source:  BioPlex
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999719184
p_ni:  0.000280816
Data Source:  BioPlex
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.885728082
p_ni:  0.114271918
Data Source:  BioPlex
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.859153089
p_ni:  0.140846911
Score:  0.366
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.793645037
p_ni:  0.206354963
Data Source:  BioPlex
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
Score:  0.875
Data Source:  STRINGDB
DDX17
Tbio
Family:  Enzyme
Novelty:  0.00462781
Score:  0.841
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
3
1
93
neuroticism measurement
5
13
6
7.3
88.8
wellbeing measurement
3
3
4
85
depressive symptom measurement
2
3
3
84
worry measurement
2
5
4
6
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
93
neuroticism measurement
6
7.3
88.8
wellbeing measurement
4
85
depressive symptom measurement
3
84
worry measurement
4
6
73.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YLP motif containing 1
VGNC:3287
453038
Macaque
YLP motif containing 1
700167
Mouse
MGI:1926195
56531
Rat
RGD:1564946
299199
Dog
YLP motif containing 1
VGNC:48494
480387
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YLP motif containing 1
Macaque
YLP motif containing 1
Mouse
Rat
Dog
YLP motif containing 1
Publication Statistics
PubMed Score 4.80
PubMed score by year
PubTator Score 0.88
PubTator score by year
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Related Publications
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PMID
Year
Title