Tdark YIPF6 Protein YIPF6

Protein Summary

Description

May be required for stable YIPF1 and YIPF2 protein expression.

Uniprot Accession IDs

• Q96EC8
• B4E1U7
• G5E997
• Q5JP08

Gene Name

• YIPF6

Ensembl ID

• ENST00000374622
• ENSP00000363751
• ENSG00000181704
• ENST00000462683
• ENSP00000417573

Symbol

• FinGER6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
transcription factor perturbation	0.91
histone modification site profile	0.87
kinase perturbation	0.76
microRNA	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.58   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.58   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (116)

Explore Interacting Targets

1 – 10 of 116

• See Interactions on String-DB

YIPF1

Tbio

Novelty:  0.00507381

p_int:  0.9851726

p_ni:  0.014534758

p_wrong:  0.000292643

Score:  0.964

Data Source:  BioPlex,STRINGDB

SLC7A1

Tbio

Family:  Transporter

Novelty:  0.00197313

p_int:  0.901820272

p_ni:  0.098179684

p_wrong:  4.4e-8

Data Source:  BioPlex

SLC7A14

Tbio

Family:  Transporter

Novelty:  0.1613451

p_int:  0.867089035

p_ni:  0.128998332

p_wrong:  0.003912633

Data Source:  BioPlex

ADGRE5

Tbio

Family:  GPCR

Novelty:  0.01137558

p_int:  0.816704618

p_ni:  0.183295024

p_wrong:  3.59e-7

Score:  0.181

Data Source:  BioPlex,STRINGDB

SPPL2B

Tchem

Family:  Enzyme

Novelty:  0.0274774

p_int:  0.803968276

p_ni:  0.196031384

p_wrong:  3.41e-7

Score:  0.156

Data Source:  BioPlex,STRINGDB

YIPF2

Tdark

Novelty:  0.01302483

Score:  0.973

Data Source:  STRINGDB

AP4E1

Tdark

Novelty:  0.09773225

Score:  0.941

Data Source:  STRINGDB

YIPF3

Tbio

Novelty:  0.12021667

Score:  0.933

Data Source:  STRINGDB

OCRL

Tbio

Family:  Enzyme

Novelty:  0.00555539

Score:  0.931

Data Source:  STRINGDB

TBC1D8B

Tdark

Novelty:  0.35419125

Score:  0.925

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Golgi Associated Vesicle Biogenesis	56 targets	R-HSA-432722
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656
Reactome	trans-Golgi Network Vesicle Budding	72 targets	R-HSA-199992

Name	Explore in Pharos	Explore in Source
Golgi Associated Vesicle Biogenesis	56 targets	R-HSA-432722
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656
trans-Golgi Network Vesicle Budding	72 targets	R-HSA-199992

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (1)

Components (8)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	1	1	1		48.5
balding measurement	EFO_0007825	1	1	1		34.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	1		48.5
balding measurement	EFO_0007825	1		34.8

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Golgi apparatus
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
testosterone measurement

MGI Phenotype Find Similar Targets

No Header	No Header
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	Yip1 domain family member 6		713477
Mouse	Yip1 domain family, member 6	MGI:1925179	77929
Rat	Yip1 domain family, member 6	RGD:1566154	363476
Dog	Yip1 domain family member 6	VGNC:48492	491931
Horse	Yip1 domain family member 6 [Source:HGNC Symbol;Acc:HGNC:28304]

Species	Name	OMA	EggNOG	Inparanoid
Macaque	Yip1 domain family member 6
Mouse	Yip1 domain family, member 6
Rat	Yip1 domain family, member 6
Dog	Yip1 domain family member 6
Horse	Yip1 domain family member 6 [Source:HGNC Symbol;Acc:HGNC:28304]

Publication Statistics

PubMed Score 18.58

PubMed score by year

Reset Zoom

PubTator Score 6.20

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (14)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title