Pharos : Target Details

Tdark

Protein Summary

Description

Involved in the maintenance of the Golgi structure.

Uniprot Accession IDs

Q9BSR8

Gene Name

YIPF4

Ensembl ID

ENST00000238831
ENSP00000238831
ENSG00000119820

Symbol

FinGER4
Nbla11189

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93

histone modification site profile	0.9

small molecule perturbation	0.64

tissue sample	0.6

transcription factor binding site profile	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.8 (req: < 5)

View Publications

Gene RIFs: 3 (req: <= 3)

View Gene RIFs

Antibodies: 84 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.8 (req: >= 5)

Gene RIFs: 3 (req: > 3)

Antibodies: 84 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (52)

Explore Interacting Targets

1 – 10 of 52

See Interactions on String-DB

CHRM3

Tclin

Family: GPCR

Novelty: 0.00849776

p_int: 0.985060761

p_ni: 0.014936763

p_wrong: 0.000002477

Data Source: BioPlex

VIPR2

Tchem

Family: GPCR

Novelty: 0.00463802

p_int: 0.98282726

p_ni: 0.017171302

p_wrong: 0.000001438

Data Source: BioPlex

TMEM63A

Tdark

Family: IC

Novelty: 0.33131011

p_int: 0.98280861

p_ni: 0.017182704

p_wrong: 0.000008685

Data Source: BioPlex

SLC7A1

Tbio

Family: Transporter

Novelty: 0.00197313

p_int: 0.976871227

p_ni: 0.023126177

p_wrong: 0.000002596

Data Source: BioPlex

RETREG3

Tdark

Novelty: 0.99215801

p_int: 0.975337991

p_ni: 0.024655778

p_wrong: 0.000006231

Score: 0.211

Data Source: BioPlex,STRINGDB

SLC22A9

Tbio

Family: Transporter

Novelty: 0.02212992

p_int: 0.971636657

p_ni: 0.028361604

p_wrong: 0.00000174

Data Source: BioPlex

SPPL2B

Tchem

Family: Enzyme

Novelty: 0.0274774

p_int: 0.96672184

p_ni: 0.033272627

p_wrong: 0.000005532

Data Source: BioPlex

KCNA5

Tclin

Family: IC

Novelty: 0.00182891

p_int: 0.96595319

p_ni: 0.034041429

p_wrong: 0.000005381

Data Source: BioPlex

YIPF3

Tbio

Novelty: 0.12021667

p_int: 0.958988644

p_ni: 0.041008607

p_wrong: 0.00000275

Score: 0.927

Data Source: BioPlex,STRINGDB

IPPK

Tbio

Family: Enzyme

Novelty: 0.02169701

p_int: 0.95587941

p_ni: 0.044118411

p_wrong: 0.000002179

Data Source: BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Components (5)

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Items per page:

1 – 5 of 5

GO Term	Evidence	Assigned by
endoplasmic reticulum	Inferred from Direct Assay (IDA)	LIFEdb

Golgi apparatus	Inferred from Direct Assay (IDA)	HPA

intracellular membrane-bounded organelle	Inferred from Direct Assay (IDA)	HPA

plasma membrane	Inferred from Direct Assay (IDA)	HPA

integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (6)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
interleukin 18 measurement	EFO_0004581	2	2	2		95.1

testosterone measurement	EFO_0004908	1	2	2		82.2

sex hormone-binding globulin measurement	EFO_0004696	4	2	4		74

pallidum volume	EFO_0006933	1	1	0	5.8	27.3

reticulocyte count	EFO_0007986	4	1	4		17.7

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
interleukin 18 measurement	EFO_0004581	2		95.1

testosterone measurement	EFO_0004908	2		82.2

sex hormone-binding globulin measurement	EFO_0004696	4		74

pallidum volume	EFO_0006933	0	5.8	27.3

reticulocyte count	EFO_0007986	4		17.7

Beta Count

Odds Ratio

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UniProt Keyword

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GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Chimp	Yip1 domain family member 4	VGNC:2915	743691

Macaque	Yip1 domain family member 4		706819

Mouse	Yip1 domain family, member 4	MGI:1915114	67864

Dog	Yip1 domain family member 4	VGNC:48490	475717

Horse	Yip1 domain family member 4	VGNC:51429	100070586

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Yip1 domain family member 4

Macaque	Yip1 domain family member 4

Mouse	Yip1 domain family, member 4

Dog	Yip1 domain family member 4

Horse	Yip1 domain family member 4

Publication Statistics

PubMed Score 4.80

PubMed score by year

PubTator Score 13.25

PubTator score by year

Related Publications

Text Mined References (15)

GeneRif Annotations (3)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Complete proteome

Golgi apparatus

Membrane

Reference proteome

Transmembrane

Transmembrane helix