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Tbio
YBX2
Y-box-binding protein 2

Protein Summary
Description
Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000007699
  • ENSP00000007699
  • ENSG00000006047

Symbol
  • CSDA3
  • MSY2
  • DBPC
  • MSY2
  • CSDA3
  • CONTRIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.69
histone modification site profile
0.69
biological process
0.68
transcription factor
0.66
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.71   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.71   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
PPAN
Tbio
Novelty:  0.01063709
p_int:  0.999997736
p_ni:  0.00000208
p_wrong:  1.85e-7
Score:  0.15
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.999994359
p_ni:  0.00000564
p_wrong:  1e-9
Score:  0.529
Data Source:  BioPlex,STRINGDB
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.999994062
p_ni:  0.000005938
Score:  0.608
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999987998
p_ni:  0.000011997
p_wrong:  5e-9
Score:  0.266
Data Source:  BioPlex,STRINGDB
ZCRB1
Tbio
Novelty:  0.37592387
p_int:  0.999973713
p_ni:  0.000026286
p_wrong:  1e-9
Score:  0.625
Data Source:  BioPlex,STRINGDB
NIFK
Tbio
Novelty:  0.01221562
p_int:  0.999877047
p_ni:  0.000122926
p_wrong:  2.7e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.999861953
p_ni:  0.0001337
p_wrong:  0.000004347
Score:  0.602
Data Source:  BioPlex,STRINGDB
FGF17
Tbio
Novelty:  0.01432991
p_int:  0.999860548
p_ni:  0.000139451
Data Source:  BioPlex
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.999791022
p_ni:  0.000208951
p_wrong:  2.7e-8
Score:  0.39
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999564868
p_ni:  0.000435112
p_wrong:  2e-8
Score:  0.301
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (60)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
5
4
2.1
98.9
birth weight
4
3
4
94.4
low density lipoprotein cholesterol measurement
4
4
5
92.5
metabolite measurement
2
3
4
90.8
apolipoprotein B measurement
2
4
4
88.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
2.1
98.9
birth weight
4
94.4
low density lipoprotein cholesterol measurement
5
92.5
metabolite measurement
4
90.8
apolipoprotein B measurement
4
88.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Y-box binding protein 2
VGNC:9793
455231
Mouse
MGI:1096372
53422
Rat
RGD:1305068
303250
Dog
Y-box binding protein 2
489467
Horse
Y-box binding protein 2 [Source:HGNC Symbol;Acc:HGNC:17948]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Y-box binding protein 2
Mouse
Rat
Dog
Y-box binding protein 2
Horse
Y-box binding protein 2 [Source:HGNC Symbol;Acc:HGNC:17948]
Publication Statistics
PubMed Score 72.71
PubMed score by year
PubTator Score 29.93
PubTator score by year
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Related Publications
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PMID
Year
Title