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Tdark
YBEY
Endoribonuclease YbeY

Protein Summary
Description
Single strand-specific metallo-endoribonuclease involved in rRNA maturation. This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329319
  • ENSP00000329614
  • ENSG00000182362
  • ENST00000339195
  • ENSP00000340675
  • ENST00000397691
  • ENSP00000380805
  • ENST00000397692
  • ENSP00000380806
  • ENST00000397694
  • ENSP00000380808
  • ENST00000397701
  • ENSP00000380813

Symbol
  • C21orf57
  • C21orf57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.74
histone modification site profile
0.64
microRNA
0.63
transcription factor binding site profile
0.63
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.25   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.25   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
BCAT2
Tchem
Family:  Enzyme
Novelty:  0.00885158
p_int:  0.999931925
p_ni:  0.000066971
p_wrong:  0.000001104
Score:  0.348
Data Source:  BioPlex,STRINGDB
GTPBP8
Tdark
Novelty:  4.38933188
p_int:  0.999717437
p_ni:  0.000282562
Score:  0.388
Data Source:  BioPlex,STRINGDB
TRMU
Tbio
Family:  Enzyme
Novelty:  0.01615197
p_int:  0.999569314
p_ni:  0.000047476
p_wrong:  0.00038321
Score:  0.345
Data Source:  BioPlex,STRINGDB
GFM2
Tbio
Novelty:  0.02945848
p_int:  0.999434314
p_ni:  0.000483257
p_wrong:  0.000082429
Data Source:  BioPlex
CHDH
Tbio
Family:  Enzyme
Novelty:  0.02147468
p_int:  0.999391426
p_ni:  0.000555463
p_wrong:  0.00005311
Score:  0.229
Data Source:  BioPlex,STRINGDB
OXNAD1
Tdark
Family:  Enzyme
Novelty:  1.38777329
p_int:  0.999276513
p_ni:  0.000148832
p_wrong:  0.000574655
Score:  0.2
Data Source:  BioPlex,STRINGDB
MTG1
Tbio
Family:  Enzyme
Novelty:  0.07182539
p_int:  0.998694118
p_ni:  0.001305876
p_wrong:  6e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
p_int:  0.997769888
p_ni:  0.002230112
Score:  0.335
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.996740967
p_ni:  0.003253963
p_wrong:  0.00000507
Data Source:  BioPlex
TFB1M
Tbio
Family:  Enzyme
Novelty:  0.0236373
p_int:  0.994073693
p_ni:  0.004891149
p_wrong:  0.001035158
Score:  0.365
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
53.7
1
1
0
1.2
52
1
1
0
1.3
35
1
1
1
33.1
1
1
0
1.1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
53.7
0
1.2
52
0
1.3
35
1
33.1
0
1.1
28.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ybeY metalloendoribonuclease
VGNC:7202
742420
Macaque
ybeY metallopeptidase (putative)
721807
Mouse
MGI:2656825
216119
Rat
RGD:1308722
361822
Dog
ybeY metalloendoribonuclease
VGNC:53052
606842
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ybeY metalloendoribonuclease
Macaque
ybeY metallopeptidase (putative)
Mouse
Rat
Dog
ybeY metalloendoribonuclease
Publication Statistics
PubMed Score 39.25
PubMed score by year
PubTator Score 3.59
PubTator score by year
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Related Publications
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PMID
Year
Title