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Tbio
YARS2
Tyrosine--tRNA ligase, mitochondrial

Protein Summary
Description
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324868
  • ENSP00000320658
  • ENSG00000139131

Symbol
  • TYRRS
  • CGI-04
  • MLASA2
  • MT-TYRRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor binding site profile
0.94
kinase perturbation
0.88
protein domain
0.85
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.52   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.52   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (182)
LYRM2
Tdark
Novelty:  0.33936166
p_int:  0.999836313
p_ni:  0.000163686
p_wrong:  1e-9
Score:  0.168
Data Source:  BioPlex,STRINGDB
TMEM184A
Tbio
Novelty:  0.16408207
p_int:  0.999456307
p_ni:  0.000543693
Data Source:  BioPlex
CDC20
Tbio
Novelty:  0.00197887
p_int:  0.998795583
p_ni:  0.001204417
Score:  0.187
Data Source:  BioPlex,STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.99865722
p_ni:  0.00134278
Score:  0.26
Data Source:  BioPlex,STRINGDB
RBM3
Tbio
Novelty:  0.01066923
p_int:  0.995667683
p_ni:  0.004332317
Score:  0.2
Data Source:  BioPlex,STRINGDB
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.995004836
p_ni:  0.004995164
Score:  0.789
Data Source:  BioPlex,STRINGDB
HNRNPDL
Tbio
Novelty:  0.00222179
p_int:  0.993355147
p_ni:  0.006644853
Score:  0.2
Data Source:  BioPlex,STRINGDB
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.989865105
p_ni:  0.010134895
Data Source:  BioPlex
RBMX
Tbio
Novelty:  0.01705784
p_int:  0.987418865
p_ni:  0.012581134
Score:  0.522
Data Source:  BioPlex,STRINGDB
CIRBP
Tbio
Novelty:  0.00439066
p_int:  0.983263881
p_ni:  0.01673612
Score:  0.2
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
94.8
3
2
0
1.1
78.2
platelet count
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
94.8
0
1.1
78.2
platelet count
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosyl-tRNA synthetase 2
VGNC:5652
473356
Macaque
tyrosyl-tRNA synthetase 2
697033
Mouse
MGI:1917370
70120
Rat
RGD:1311696
287924
Dog
tyrosyl-tRNA synthetase 2
VGNC:48479
486614
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosyl-tRNA synthetase 2
Macaque
tyrosyl-tRNA synthetase 2
Mouse
Rat
Dog
tyrosyl-tRNA synthetase 2
Publication Statistics
PubMed Score 190.52
PubMed score by year
PubTator Score 25.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title