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Tchem
YARS
Tyrosine--tRNA ligase, cytoplasmic

Protein Summary
Description
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373477
  • ENSP00000362576
  • ENSG00000134684

Symbol
  • YRS
  • YTS
  • TYRRS
  • CMTDIC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.98
transcription factor binding site profile
0.94
co-expressed gene
0.87
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.15   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.15   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (489)
TRIM5
Tbio
Novelty:  0.00289445
p_int:  0.927657076
p_ni:  0.072342924
Score:  0.516
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.794309817
p_ni:  0.205690183
Score:  0.177
Data Source:  BioPlex,STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.998
Data Source:  STRINGDB
QARS
Tchem
Family:  Enzyme
Novelty:  0.01684657
Score:  0.997
Data Source:  STRINGDB
MARS
Tchem
Family:  Enzyme
Novelty:  0.01318702
Score:  0.993
Data Source:  STRINGDB
AARS
Tbio
Family:  Enzyme
Novelty:  0.00203732
Score:  0.99
Data Source:  STRINGDB
IARS
Tchem
Family:  Enzyme
Novelty:  0.00539046
Score:  0.988
Data Source:  STRINGDB
CARS
Tchem
Family:  Enzyme
Novelty:  0.02078279
Score:  0.986
Data Source:  STRINGDB
LARS
Tchem
Family:  Enzyme
Novelty:  0.00361711
Score:  0.986
Data Source:  STRINGDB
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism of proteins
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism of proteins
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
60.2
body mass index
1
1
1
59
visceral adipose tissue measurement
1
1
1
33.1
daytime rest measurement
1
1
1
15.7
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
60.2
body mass index
1
59
visceral adipose tissue measurement
1
33.1
daytime rest measurement
1
15.7
1
2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosyl-tRNA synthetase
VGNC:8122
469266
Macaque
tyrosyl-tRNA synthetase
709003
Mouse
MGI:2147627
107271
Rat
RGD:1307616
313047
Dog
tyrosyl-tRNA synthetase
VGNC:48478
478148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosyl-tRNA synthetase
Macaque
tyrosyl-tRNA synthetase
Mouse
Rat
Dog
tyrosyl-tRNA synthetase
Publication Statistics
PubMed Score 312.15
PubMed score by year
PubTator Score 46.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title