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Tchem
YAP1
Transcriptional coactivator YAP1

Protein Summary
Description
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282441
  • ENSP00000282441
  • ENSG00000137693
  • ENST00000345877
  • ENSP00000331023
  • ENST00000524575
  • ENSP00000435602
  • ENST00000526343
  • ENSP00000434134
  • ENST00000531439
  • ENSP00000431574
  • ENST00000537274
  • ENSP00000445635
  • ENST00000615667
  • ENSP00000478927
  • ENST00000629586
  • ENSP00000487519

Symbol
  • YAP65
  • YAP
  • YKI
  • COB1
  • YAP2
  • YAP65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
biological term
0.96
ligand (protein) perturbation
0.96
kinase
0.9
hub protein
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1308.92   (req: < 5)
Gene RIFs: 584   (req: <= 3)
Antibodies: 815   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1308.92   (req: >= 5)
Gene RIFs: 584   (req: > 3)
Antibodies: 815   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0