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Tbio
XYLB
Xylulose kinase

Protein Summary
Description
Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000207870
  • ENSP00000207870
  • ENSG00000093217
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
cell type or tissue
0.79
tissue sample
0.7
disease perturbation
0.68
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.12   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.12   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
RPE
Tbio
Family:  Enzyme
Novelty:  0.01035554
Score:  0.983
Data Source:  STRINGDB
RPEL1
Tbio
Family:  Enzyme
Novelty:  0.40871656
Score:  0.965
Data Source:  STRINGDB
SLC22A14
Tdark
Family:  Transporter
Novelty:  0.3340737
Score:  0.931
Data Source:  STRINGDB
TALDO1
Tbio
Family:  Enzyme
Novelty:  0.00208619
Score:  0.928
Data Source:  STRINGDB
SLC22A13
Tbio
Family:  Transporter
Novelty:  0.04702774
Score:  0.911
Data Source:  STRINGDB
XDH
Tclin
Family:  Enzyme
Novelty:  0.00054185
Score:  0.875
Data Source:  STRINGDB
SORD
Tchem
Family:  Enzyme
Novelty:  0.0040485
Score:  0.858
Data Source:  STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
Score:  0.809
Data Source:  STRINGDB
OXSR1
Tbio
Family:  Kinase
Novelty:  0.11142923
Score:  0.8
Data Source:  STRINGDB
AKR1B1
Tclin
Family:  Enzyme
Novelty:  0.00045769
Score:  0.784
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Formation of xylulose-5-phosphate (R-HSA-5661270)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of xylulose-5-phosphate
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Formation of xylulose-5-phosphate
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
4
3
6.6
91.6
QRS duration
2
2
1
8.2
77.7
QT interval
4
3
0
1.5
76.1
red blood cell distribution width
2
1
2
71.3
appendicular lean mass
1
2
2
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
6.6
91.6
QRS duration
1
8.2
77.7
QT interval
0
1.5
76.1
red blood cell distribution width
2
71.3
appendicular lean mass
2
58.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
xylulokinase
VGNC:12242
470793
Macaque
xylulokinase
695879
Mouse
MGI:2142985
102448
Rat
RGD:1307372
316067
Dog
xylulokinase
VGNC:48474
609126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
xylulokinase
Macaque
xylulokinase
Mouse
Rat
Dog
xylulokinase
Publication Statistics
PubMed Score 181.12
PubMed score by year
PubTator Score 12.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title