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Tbio
XRCC5
X-ray repair cross-complementing protein 5

Protein Summary
Description
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:20383123). The XRCC5/6 dimer probably also ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392132
  • ENSP00000375977
  • ENSG00000079246
  • ENST00000392133
  • ENSP00000375978

Symbol
  • G22P2
  • KU80
  • KUB2
  • Ku86
  • NFIV
  • KARP1
  • KARP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
co-expressed gene
0.99
transcription factor perturbation
0.99
virus perturbation
0.99
hub protein
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.77   (req: < 5)
Gene RIFs: 153   (req: <= 3)
Antibodies: 1075   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.77   (req: >= 5)
Gene RIFs: 153   (req: > 3)
Antibodies: 1075   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (333)
XRCC6
Tbio
Novelty:  0.00127955
p_int:  0.997223271
p_ni:  0.002776729
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
APLF
Tbio
Novelty:  0.01347476
p_int:  0.995383501
p_ni:  0.004616499
Score:  0.992
Data Source:  BioPlex,STRINGDB
CDK5RAP1
Tbio
Novelty:  0.0347805
p_int:  0.929693842
p_ni:  0.070306158
Score:  0.826
Data Source:  BioPlex,STRINGDB
PRKDC
Tchem
Family:  Kinase
Novelty:  0.00107984
Score:  0.999
Data Source:  Reactome,STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.997
Data Source:  Reactome,STRINGDB
XRCC4
Tbio
Novelty:  0.00305644
Score:  0.996
Data Source:  Reactome,STRINGDB
LIG4
Tbio
Family:  Enzyme
Novelty:  0.00412993
Score:  0.994
Data Source:  Reactome,STRINGDB
MRE11
Tbio
Novelty:  0.01038348
Score:  0.994
Data Source:  Reactome,STRINGDB
NHEJ1
Tbio
Novelty:  0.00773499
Score:  0.993
Data Source:  Reactome,STRINGDB
RAD50
Tbio
Novelty:  0.02161298
Score:  0.992
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
2-LTR circle formation (R-HSA-164843)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
2-LTR circle formation
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Disease
Name
Explore in Pharos
Explore in Source
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
DNA Double-Strand Break Repair
DNA Repair
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (57)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
49.5
1
1
0
1.4
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
49.5
0
1.4
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
X-ray repair cross complementing 5
VGNC:3879
449614
Macaque
X-ray repair cross complementing 5
574279
Mouse
MGI:104517
22596
Rat
RGD:3976
363247
Dog
X-ray repair cross complementing 5
VGNC:48469
478902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
X-ray repair cross complementing 5
Macaque
X-ray repair cross complementing 5
Mouse
Rat
Dog
X-ray repair cross complementing 5
Publication Statistics
PubMed Score 638.77
PubMed score by year
PubTator Score 481.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title