Tbio XRCC4 DNA repair protein XRCC4

Protein Summary

Description

Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q13426
• A8K3X4
• Q9BS72
• Q9UP94

Gene Name

• XRCC4

Ensembl ID

• ENST00000282268
• ENSP00000282268
• ENSG00000152422
• ENST00000338635
• ENSP00000342011
• ENST00000396027
• ENSP00000379344
• ENST00000511817
• ENSP00000421491

Symbol

• SSMED

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.89
histone modification site profile	0.89
transcription factor perturbation	0.84
transcription factor binding site profile	0.71
cellular component	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.49   (req: < 5)

Gene RIFs: 151   (req: <= 3)

Antibodies: 414   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.49   (req: >= 5)

Gene RIFs: 151   (req: > 3)

Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0