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Tbio
XRCC2
DNA repair protein XRCC2

Protein Summary
Description
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359321
  • ENSP00000352271
  • ENSG00000196584

Symbol
  • FANCU
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
histone modification site profile
0.9
cell type or tissue
0.77
small molecule perturbation
0.76
biological process
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.62   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.62   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
ARL4C
Tbio
Family:  Enzyme
Novelty:  0.04764628
p_int:  0.999999058
p_ni:  7.86e-7
p_wrong:  1.56e-7
Score:  0.697
Data Source:  BioPlex,STRINGDB
RAD51D
Tbio
Novelty:  0.01422516
p_int:  0.999992702
p_ni:  0.000007293
p_wrong:  5e-9
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.99995788
p_ni:  0.00002701
p_wrong:  0.00001511
Score:  0.735
Data Source:  BioPlex,STRINGDB
RAD51B
Tbio
Novelty:  0.00302521
p_int:  0.999935327
p_ni:  0.000064673
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.998991236
p_ni:  0.000135882
p_wrong:  0.000872882
Score:  0.527
Data Source:  BioPlex,STRINGDB
RAD51C
Tbio
Novelty:  0.0063568
p_int:  0.994666946
p_ni:  0.005333054
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
NMB
Tbio
Novelty:  0.00729571
p_int:  0.893774048
p_ni:  0.000139599
p_wrong:  0.106086353
Data Source:  BioPlex
XRCC3
Tbio
Novelty:  0.00266163
Score:  0.995
Data Source:  STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
Score:  0.984
Data Source:  STRINGDB
PALB2
Tbio
Novelty:  0.00320056
Score:  0.97
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome
Homologous DNA Pairing and Strand Exchange
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Homologous DNA Pairing and Strand Exchange
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
4
96
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
96
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
X-ray repair cross complementing 2
VGNC:4566
738997
Macaque
X-ray repair cross complementing 2
717006
Mouse
MGI:1927345
57434
Rat
RGD:1564823
499966
Dog
X-ray repair cross complementing 2
VGNC:48466
475548
Species
Name
OMA
EggNOG
Inparanoid
Chimp
X-ray repair cross complementing 2
Macaque
X-ray repair cross complementing 2
Mouse
Rat
Dog
X-ray repair cross complementing 2
Publication Statistics
PubMed Score 120.62
PubMed score by year
PubTator Score 105.93
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title