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Tbio
XPR1
Xenotropic and polytropic retrovirus receptor 1

Protein Summary
Description
Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed:23791524, PubMed:25938945). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106). The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367589
  • ENSP00000356561
  • ENSG00000143324
  • ENST00000367590
  • ENSP00000356562

Symbol
  • SYG1
  • XR
  • X3
  • SYG1
  • IBGC6
  • SLC53A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor perturbation
0.94
kinase perturbation
0.91
ligand (protein) perturbation
0.83
small molecule perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.11   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.11   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
KIDINS220
Tbio
Family:  Enzyme
Novelty:  0.02169147
p_int:  0.999996554
p_ni:  0.000003446
Score:  0.828
Data Source:  BioPlex,STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.999915297
p_ni:  0.000084703
Data Source:  BioPlex
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.998521957
p_ni:  0.00147804
p_wrong:  3e-9
Score:  0.238
Data Source:  BioPlex,STRINGDB
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.997928969
p_ni:  0.002071031
Data Source:  BioPlex
CD226
Tbio
Novelty:  0.00374102
p_int:  0.99475356
p_ni:  0.005246277
p_wrong:  1.63e-7
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.992640382
p_ni:  0.007359617
p_wrong:  1e-9
Data Source:  BioPlex
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.99121614
p_ni:  0.00878386
Data Source:  BioPlex
VSTM1
Tbio
Novelty:  0.08630646
p_int:  0.989420985
p_ni:  0.010578939
p_wrong:  7.7e-8
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.987413324
p_ni:  0.01258657
p_wrong:  1.05e-7
Data Source:  BioPlex
RHOT2
Tbio
Family:  Enzyme
Novelty:  0.01712732
p_int:  0.974953217
p_ni:  0.025046783
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
72.9
systolic blood pressure
1
1
1
63.4
glomerular filtration rate
3
1
2
7.2
62.5
myeloid white cell count
1
1
1
61.4
leukocyte count
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
72.9
systolic blood pressure
1
63.4
glomerular filtration rate
2
7.2
62.5
myeloid white cell count
1
61.4
leukocyte count
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
xenotropic and polytropic retrovirus receptor 1
VGNC:1637
469603
Macaque
xenotropic and polytropic retrovirus receptor 1
716337
Mouse
MGI:97932
19775
Rat
RGD:1306554
289424
Dog
xenotropic and polytropic retrovirus receptor 1
490301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
xenotropic and polytropic retrovirus receptor 1
Macaque
xenotropic and polytropic retrovirus receptor 1
Mouse
Rat
Dog
xenotropic and polytropic retrovirus receptor 1
Publication Statistics
PubMed Score 144.11
PubMed score by year
PubTator Score 227.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title