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Tbio
XPO7
Exportin-7

Protein Summary
Description
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of on ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252512
  • ENSP00000252512
  • ENSG00000130227

Symbol
  • KIAA0745
  • RANBP16
  • EXP7
  • RANBP16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
0.99
disease perturbation
0.98
transcription factor perturbation
0.97
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.26   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.26   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.999936739
p_ni:  0.000063261
Data Source:  BioPlex
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
p_int:  0.999567385
p_ni:  0.000432615
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.999565193
p_ni:  0.000434807
Data Source:  BioPlex
CD274
Tclin
Novelty:  0.00013449
p_int:  0.998852991
p_ni:  0.001147009
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.998090028
p_ni:  0.001909972
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.995426302
p_ni:  0.004573698
Data Source:  BioPlex
RP2
Tbio
Novelty:  0.12345247
p_int:  0.993678749
p_ni:  0.006321251
Data Source:  BioPlex
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.992676544
p_ni:  0.007323456
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.987786775
p_ni:  0.012213225
Data Source:  BioPlex
VASN
Tbio
Novelty:  0.05424159
p_int:  0.986930693
p_ni:  0.013069307
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
3
4
95.8
mean corpuscular hemoglobin concentration
2
2
2
95
mean reticulocyte volume
1
2
2
94.7
serum gamma-glutamyl transferase measurement
2
2
2
94.5
red blood cell density measurement
2
2
2
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
95.8
mean corpuscular hemoglobin concentration
2
95
mean reticulocyte volume
2
94.7
serum gamma-glutamyl transferase measurement
2
94.5
red blood cell density measurement
2
92.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exportin 7
VGNC:760
464037
Macaque
exportin 7
715398
Mouse
MGI:1929705
65246
Rat
RGD:1310928
361070
Dog
exportin 7
VGNC:48464
477387
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exportin 7
Macaque
exportin 7
Mouse
Rat
Dog
exportin 7
Publication Statistics
PubMed Score 20.26
PubMed score by year
PubTator Score 7.59
PubTator score by year
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Related Publications
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PMID
Year
Title