Protein Summary
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of on ...more
- ENST00000252512
- ENSP00000252512
- ENSG00000130227
- KIAA0745
- RANBP16
- EXP7
- RANBP16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
interacting protein | 0.99 | ||
disease perturbation | 0.98 | ||
transcription factor perturbation | 0.97 | ||
kinase perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.26 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 118 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.26 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 118 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (91)
NT5E
Family: Enzyme
Novelty: 0.00083237
p_int: 0.999567385
p_ni: 0.000432615
Data Source: BioPlex
VIPR2
Family: GPCR
Novelty: 0.00463802
p_int: 0.998090028
p_ni: 0.001909972
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 4 | 3 | 4 | 95.8 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 95 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 94.7 | |||||
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 94.5 | |||||
red blood cell density measurement | 2 | 2 | 2 | 92.1 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 4 | 95.8 | |||||
mean corpuscular hemoglobin concentration | 2 | 95 | |||||
mean reticulocyte volume | 2 | 94.7 | |||||
serum gamma-glutamyl transferase measurement | 2 | 94.5 | |||||
red blood cell density measurement | 2 | 92.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | exportin 7 | VGNC:760 | 464037 | |||||
Macaque | exportin 7 | 715398 | ||||||
Mouse | MGI:1929705 | 65246 | ||||||
Rat | RGD:1310928 | 361070 | ||||||
Dog | exportin 7 | VGNC:48464 | 477387 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | exportin 7 | |||||
Macaque | exportin 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | exportin 7 | |||||
Publication Statistics
PubMed Score 20.26
PubMed score by year
PubTator Score 7.59
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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