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Tbio
XPO6
Exportin-6

Protein Summary
Description
Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304658
  • ENSP00000302790
  • ENSG00000169180
  • ENST00000565698
  • ENSP00000457341

Symbol
  • KIAA0370
  • RANBP20
  • EXP6
  • RANBP20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.99
kinase perturbation
0.88
transcription factor binding site profile
0.86
transcription factor
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.34   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.34   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.999944101
p_ni:  0.000055899
Data Source:  BioPlex
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.999769657
p_ni:  0.000230343
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.999476655
p_ni:  0.000523345
Score:  0.203
Data Source:  BioPlex,STRINGDB
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.997547629
p_ni:  0.00245237
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.997293722
p_ni:  0.002705449
p_wrong:  8.29e-7
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.99351374
p_ni:  0.00648626
Data Source:  BioPlex
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.993283415
p_ni:  0.006716585
Data Source:  BioPlex
CA14
Tclin
Family:  Enzyme
Novelty:  0.00864764
p_int:  0.989910005
p_ni:  0.010089995
Data Source:  BioPlex
CD83
Tbio
Novelty:  0.00138653
p_int:  0.988376584
p_ni:  0.011623416
Data Source:  BioPlex
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.985416154
p_ni:  0.014583844
p_wrong:  3e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
3
2
5.8
61.3
monocyte count
1
1
1
59.9
apolipoprotein A 1 measurement
2
2
2
59.6
myeloid white cell count
1
1
1
53.7
mathematical ability
2
2
2
42.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
5.8
61.3
monocyte count
1
59.9
apolipoprotein A 1 measurement
2
59.6
myeloid white cell count
1
53.7
mathematical ability
2
42.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exportin 6
VGNC:5957
454011
Mouse
MGI:2429950
74204
Rat
RGD:1311491
293476
Dog
exportin 6
VGNC:48463
479798
Horse
exportin 6
VGNC:25078
100064463
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exportin 6
Mouse
Rat
Dog
exportin 6
Horse
exportin 6
Publication Statistics
PubMed Score 32.34
PubMed score by year
PubTator Score 32.79
PubTator score by year
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Related Publications
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PMID
Year
Title