Tbio XPO5 Exportin-5

Protein Summary

Description

Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner. Mediates the nuclear export of micro-RNA precursors, which form short hairpins (PubMed:14681208, PubMed:14631048, PubMed:15613540). Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs (PubMed:19965479). Binding is dependent on Ran-GTP (PubMed:19965479). (Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA. This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9HAV4
• Q5JTE6
• Q96G48
• Q96HN3
• Q9BWM6
• Q9BZV5
• Q9H9M4
• Q9NT89
• Q9NW39
• Q9ULC9
• Exp5

Gene Name

• XPO5

Ensembl ID

• ENST00000265351
• ENSP00000265351
• ENSG00000124571

Symbol

• KIAA1291
• RANBP21
• exp5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
histone modification site profile	0.9
virus perturbation	0.9
transcription factor perturbation	0.88
transcription factor binding site profile	0.82

Protein Classes

PANTHER Classes

Protein / Receptor / Exportin-5

DTO Classes

Protein / Receptor / Exportin-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.44   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.44   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (122)

Explore Interacting Targets

1 – 10 of 122

• See Interactions on String-DB

CLEC12A

Tbio

Novelty:  0.01478908

p_int:  0.999771535

p_ni:  0.000228465

Score:  0.205

Data Source:  BioPlex,STRINGDB

NCR3LG1

Tbio

Novelty:  0.02681936

p_int:  0.994262458

p_ni:  0.005737542

Score:  0.169

Data Source:  BioPlex,STRINGDB

TMEM130

Tdark

Novelty:  1.39618601

p_int:  0.987813731

p_ni:  0.012186269

Data Source:  BioPlex

VSIG2

Tdark

Novelty:  0.32398032

p_int:  0.963747912

p_ni:  0.036252088

Score:  0.169

Data Source:  BioPlex,STRINGDB

RALB

Tbio

Family:  Enzyme

Novelty:  0.01605746

p_int:  0.903314533

p_ni:  0.096685467

Score:  0.245

Data Source:  BioPlex,STRINGDB

VSTM1

Tbio

Novelty:  0.08630646

p_int:  0.890378007

p_ni:  0.109621993

Data Source:  BioPlex

TMEM9

Tbio

Novelty:  0.06916197

p_int:  0.881164454

p_ni:  0.118835546

Data Source:  BioPlex

PVR

Tbio

Novelty:  0.00215811

p_int:  0.877388904

p_ni:  0.122611096

Score:  0.179

Data Source:  BioPlex,STRINGDB

TSPAN31

Tbio

Novelty:  0.13580467

p_int:  0.83855265

p_ni:  0.16144735

Data Source:  BioPlex

IFT20

Tbio

Novelty:  0.03005088

p_int:  0.83686178

p_ni:  0.16313822

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (3)

KEGG (1)

WikiPathways (2)

Gene Silencing by RNA (R-HSA-211000)

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Find Similar Targets

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene Silencing by RNA	106 targets	R-HSA-211000
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	MicroRNA (miRNA) biogenesis	24 targets	R-HSA-203927

Name	Explore in Pharos	Explore in Source
Gene Silencing by RNA	106 targets	R-HSA-211000
Gene expression (Transcription)	1452 targets	R-HSA-74160
MicroRNA (miRNA) biogenesis	24 targets	R-HSA-203927

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (7)

Components (7)

Processes (5)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
mRNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
pre-miRNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
Ran GTPase binding	Inferred from Direct Assay (IDA)	BHF-UCL
nuclear export signal receptor activity	Inferred from Mutant Phenotype (IMP)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
protein transporter activity	Inferred from Electronic Annotation (IEA)	Ensembl
tRNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	1	2	2		58.2
mathematical ability	EFO_0004875	2	1	2		56.6
creatinine measurement	EFO_0004518	1	2	2		55.8
platelet count	EFO_0004309	1	1	1		52.7
body mass index	EFO_0004340	2	1	2		52

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	2		58.2
mathematical ability	EFO_0004875	2		56.6
creatinine measurement	EFO_0004518	2		55.8
platelet count	EFO_0004309	1		52.7
body mass index	EFO_0004340	2		52

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Nucleus
Phosphoprotein
Polymorphism
Protein transport
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
body height
body mass index
creatinine measurement
glomerular filtration rate
mathematical ability
platelet count

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	exportin 5	VGNC:3790	472014
Macaque	exportin 5		700664
Mouse	exportin 5	MGI:1913789	72322
Rat	exportin 5	RGD:1311522	363194
Dog	exportin 5	VGNC:48462	474913

Species	Name	OMA	EggNOG	Inparanoid
Chimp	exportin 5
Macaque	exportin 5
Mouse	exportin 5
Rat	exportin 5
Dog	exportin 5

Publication Statistics

PubMed Score 204.44

PubMed score by year

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PubTator Score 71.65

PubTator score by year

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Related Publications

Text Mined References (58)

GeneRif Annotations (36)

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10

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PMID	Year	Title