Protein Summary
Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-media ...more
- ENST00000265351
- ENSP00000265351
- ENSG00000124571
- KIAA1291
- RANBP21
- exp5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 1 | ||
histone modification site profile | 0.9 | ||
virus perturbation | 0.9 | ||
transcription factor perturbation | 0.88 | ||
transcription factor binding site profile | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 204.44 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 208 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 204.44 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 208 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (122)
CLEC12A
Novelty: 0.01478908
p_int: 0.999771535
p_ni: 0.000228465
Score: 0.205
Data Source: BioPlex,STRINGDB
NCR3LG1
Novelty: 0.02681936
p_int: 0.994262458
p_ni: 0.005737542
Score: 0.169
Data Source: BioPlex,STRINGDB
VSIG2
Novelty: 0.32398032
p_int: 0.963747912
p_ni: 0.036252088
Score: 0.169
Data Source: BioPlex,STRINGDB
RALB
Family: Enzyme
Novelty: 0.01605746
p_int: 0.903314533
p_ni: 0.096685467
Score: 0.245
Data Source: BioPlex,STRINGDB
PVR
Novelty: 0.00215811
p_int: 0.877388904
p_ni: 0.122611096
Score: 0.179
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (3)
KEGG (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gene Silencing by RNA | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | MicroRNA (miRNA) biogenesis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gene Silencing by RNA | ||||
Gene expression (Transcription) | ||||
MicroRNA (miRNA) biogenesis | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (7)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 1 | 2 | 2 | 58.2 | |||||
mathematical ability | 2 | 1 | 2 | 56.6 | |||||
creatinine measurement | 1 | 2 | 2 | 55.8 | |||||
platelet count | 1 | 1 | 1 | 52.7 | |||||
body mass index | 2 | 1 | 2 | 52 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 58.2 | |||||
mathematical ability | 2 | 56.6 | |||||
creatinine measurement | 2 | 55.8 | |||||
platelet count | 1 | 52.7 | |||||
body mass index | 2 | 52 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | exportin 5 | VGNC:3790 | 472014 | |||||
Macaque | exportin 5 | 700664 | ||||||
Mouse | MGI:1913789 | 72322 | ||||||
Rat | RGD:1311522 | 363194 | ||||||
Dog | exportin 5 | VGNC:48462 | 474913 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | exportin 5 | |||||
Macaque | exportin 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | exportin 5 | |||||
Publication Statistics
PubMed Score 204.44
PubMed score by year
PubTator Score 71.65
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (36)
Items per page:
0 of 0
PMID | Year | Title |
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