Protein Summary
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus fro ...more
- ENST00000401558
- ENSP00000384863
- ENSG00000082898
- ENST00000404992
- ENSP00000385942
- ENST00000406957
- ENSP00000385559
- CRM1
- emb
- CRM1
- exp1
- CRM-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
hub protein | 1 | ||
transcription factor binding site profile | 0.95 | ||
transcription factor perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1321.56 (req: < 5)
Gene RIFs: 175 (req: <= 3)
Antibodies: 315 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1321.56 (req: >= 5)
Gene RIFs: 175 (req: > 3)
Antibodies: 315 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 28
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (28)
Protein-Protein Interactions (528)
LPAR4
Family: GPCR
Novelty: 0.02200758
p_int: 0.865020057
p_ni: 0.134979943
Score: 0.187
Data Source: BioPlex,STRINGDB
APLNR
Family: GPCR
Novelty: 0.00224203
p_int: 0.781738634
p_ni: 0.218261366
Score: 0.185
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (62)
Reactome (47)
KEGG (4)
PathwayCommons (10)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Reactome | Amplification of signal from the kinetochores | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Amplification of signal from the kinetochores | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cell Cycle, Mitotic | ||||
Viral Interactions (0)
Gene Ontology Terms (37)
Functions (6)
Components (15)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | ParkinsonsUK-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
myeloid white cell count | 2 | 2 | 2 | 90.7 | |||||
neutrophil count | 2 | 2 | 2 | 89 | |||||
leukocyte count | 2 | 2 | 2 | 88.6 | |||||
mean corpuscular volume | 1 | 1 | 1 | 82.8 | |||||
chronotype measurement | 2 | 2 | 1 | 1 | 79.5 | ||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
myeloid white cell count | 2 | 90.7 | |||||
neutrophil count | 2 | 89 | |||||
leukocyte count | 2 | 88.6 | |||||
mean corpuscular volume | 1 | 82.8 | |||||
chronotype measurement | 1 | 1 | 79.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | exportin 1 | VGNC:477 | 459534 | |||||
Macaque | exportin 1 | 718063 | ||||||
Mouse | MGI:2144013 | 103573 | ||||||
Rat | RGD:620517 | 85252 | ||||||
Dog | exportin 1 | VGNC:48460 | 474609 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | exportin 1 | |||||
Macaque | exportin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | exportin 1 | |||||
Publication Statistics
PubMed Score 1321.56
PubMed score by year
PubTator Score 824.15
PubTator score by year
Related Publications
Text Mined References (273)
GeneRif Annotations (175)
Items per page:
0 of 0
PMID | Year | Title |
|---|