XPNPEP3
Xaa-Pro aminopeptidase 3
Protein Summary
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889). Isoform 1: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling. The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted fo ...more
- ENST00000357137
- ENSP00000349658
- ENSG00000196236
- APP3
- ICP55
- NPHPL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.76 | ||
histone modification site profile | 0.71 | ||
microRNA | 0.71 | ||
small molecule perturbation | 0.71 | ||
tissue sample | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 133 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 133 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (69)
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Ciliary landscape | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ciliary landscape | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (4)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | MGI | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 2 | 3 | 83.8 | |||||
low density lipoprotein cholesterol measurement | 5 | 4 | 5 | 81.6 | |||||
neuroticism measurement | 3 | 3 | 1 | 6.4 | 71.9 | ||||
C-reactive protein measurement | 2 | 2 | 2 | 71.8 | |||||
basophil count | 2 | 2 | 2 | 69 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 83.8 | |||||
low density lipoprotein cholesterol measurement | 5 | 81.6 | |||||
neuroticism measurement | 1 | 6.4 | 71.9 | ||||
C-reactive protein measurement | 2 | 71.8 | |||||
basophil count | 2 | 69 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | X-prolyl aminopeptidase 3 | VGNC:12947 | 458859 | |||||
Macaque | X-prolyl aminopeptidase 3 | 705778 | ||||||
Mouse | MGI:2445217 | 321003 | ||||||
Rat | RGD:1589063 | 685823 | ||||||
Dog | X-prolyl aminopeptidase 3 | VGNC:48459 | 481237 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | X-prolyl aminopeptidase 3 | |||||
Macaque | X-prolyl aminopeptidase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | X-prolyl aminopeptidase 3 | |||||
Publication Statistics
PubMed Score 38.00
PubMed score by year
PubTator Score 21.78
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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