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Tbio
XPNPEP3
Xaa-Pro aminopeptidase 3

Protein Summary
Description
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889). Isoform 1: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling. The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted fo ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
histone modification site profile
0.71
microRNA
0.71
small molecule perturbation
0.71
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
PYY
Tbio
Novelty:  0.00060997
p_int:  0.975314727
p_ni:  0.024685273
Data Source:  BioPlex
LSMEM2
Tdark
Novelty:  43
p_int:  0.972328722
p_ni:  0.027671278
Data Source:  BioPlex
XPNPEP2
Tchem
Family:  Enzyme
Novelty:  0.01453123
Score:  0.836
Data Source:  STRINGDB
MIPEP
Tbio
Family:  Enzyme
Novelty:  0.01507033
Score:  0.803
Data Source:  STRINGDB
XPNPEP1
Tchem
Family:  Enzyme
Novelty:  0.00345088
Score:  0.801
Data Source:  STRINGDB
ALMS1
Tbio
Novelty:  0.00694228
Score:  0.8
Data Source:  STRINGDB
DNAAF1
Tbio
Novelty:  0.03962936
Score:  0.796
Data Source:  STRINGDB
ANKS3
Tbio
Novelty:  0.19978252
Score:  0.726
Data Source:  STRINGDB
NPEPPS
Tchem
Family:  Enzyme
Novelty:  0.01214136
Score:  0.647
Data Source:  STRINGDB
ERAP2
Tchem
Family:  Enzyme
Novelty:  0.01100517
Score:  0.647
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
83.8
low density lipoprotein cholesterol measurement
5
4
5
81.6
neuroticism measurement
3
3
1
6.4
71.9
C-reactive protein measurement
2
2
2
71.8
basophil count
2
2
2
69
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
83.8
low density lipoprotein cholesterol measurement
5
81.6
neuroticism measurement
1
6.4
71.9
C-reactive protein measurement
2
71.8
basophil count
2
69
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
X-prolyl aminopeptidase 3
VGNC:12947
458859
Macaque
X-prolyl aminopeptidase 3
705778
Mouse
MGI:2445217
321003
Rat
RGD:1589063
685823
Dog
X-prolyl aminopeptidase 3
VGNC:48459
481237
Species
Name
OMA
EggNOG
Inparanoid
Chimp
X-prolyl aminopeptidase 3
Macaque
X-prolyl aminopeptidase 3
Mouse
Rat
Dog
X-prolyl aminopeptidase 3
Publication Statistics
PubMed Score 38.00
PubMed score by year
PubTator Score 21.78
PubTator score by year
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Related Publications
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PMID
Year
Title