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Tchem
XPNPEP1
Xaa-Pro aminopeptidase 1

Protein Summary
Description
Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322238
  • ENSP00000324011
  • ENSG00000108039
  • ENST00000502935
  • ENSP00000421566

Symbol
  • XPNPEPL
  • XPNPEPL1
  • APP1
  • SAMP
  • XPNPEP
  • XPNPEPL
  • XPNPEPL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.96
disease perturbation
0.93
cell type or tissue
0.78
histone modification site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.96   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.96   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (79)
SPIN2B
Tchem
Novelty:  0.23202718
p_int:  0.999996273
p_ni:  0.000003727
Score:  0.246
Data Source:  BioPlex,STRINGDB
WDR4
Tbio
Family:  Enzyme
Novelty:  0.06887397
p_int:  0.888266564
p_ni:  0.111477151
p_wrong:  0.000256285
Score:  0.357
Data Source:  BioPlex,STRINGDB
RAB30
Tbio
Family:  Enzyme
Novelty:  0.1262404
p_int:  0.8734599
p_ni:  0.126540089
p_wrong:  1.1e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
RNF20
Tbio
Family:  Enzyme
Novelty:  0.01238827
Score:  0.826
Data Source:  STRINGDB
CIAPIN1
Tbio
Novelty:  0.01359005
Score:  0.824
Data Source:  STRINGDB
TMEM201
Tbio
Novelty:  0.00616362
Score:  0.805
Data Source:  STRINGDB
XPNPEP3
Tbio
Family:  Enzyme
Novelty:  0.02209842
Score:  0.801
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.788
Data Source:  STRINGDB
LAP3
Tchem
Family:  Enzyme
Novelty:  0.00327467
Score:  0.786
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.777
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
60.5
educational attainment
1
1
1
57.7
1
1
0
1.8
54.3
self reported educational attainment
1
1
1
49.1
1
1
0
1.1
46.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
60.5
educational attainment
1
57.7
0
1.8
54.3
self reported educational attainment
1
49.1
0
1.1
46.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
X-prolyl aminopeptidase 1
VGNC:13057
450726
Macaque
X-prolyl aminopeptidase 1
696570
Mouse
MGI:2180003
170750
Rat
RGD:621274
170751
Dog
X-prolyl aminopeptidase 1
VGNC:48457
486880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
X-prolyl aminopeptidase 1
Macaque
X-prolyl aminopeptidase 1
Mouse
Rat
Dog
X-prolyl aminopeptidase 1
Publication Statistics
PubMed Score 130.96
PubMed score by year
PubTator Score 59.83
PubTator score by year
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Related Publications
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PMID
Year
Title