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Tbio
XPC
DNA repair protein complementing XP-C cells

Protein Summary
Description
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285021
  • ENSP00000285021
  • ENSG00000154767
  • ENST00000476581
  • ENSP00000424548

Symbol
  • XPCC
  • XP3
  • RAD4
  • XPCC
  • p125
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.93
disease perturbation
0.87
protein domain
0.85
histone modification site profile
0.84
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.78   (req: < 5)
Gene RIFs: 210   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.78   (req: >= 5)
Gene RIFs: 210   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (222)
CETN1
Tbio
Novelty:  0.01208917
p_int:  1
Score:  0.76
Data Source:  BioPlex,STRINGDB
HIST1H2BO
Tdark
Novelty:  0.3427419
p_int:  0.999999918
p_ni:  8.2e-8
Score:  0.567
Data Source:  BioPlex,STRINGDB
HIST1H2BD
Tbio
Novelty:  0.05094332
p_int:  0.999999877
p_ni:  1.23e-7
Score:  0.71
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999988634
p_ni:  0.000011366
Score:  0.412
Data Source:  BioPlex,STRINGDB
CETN2
Tbio
Novelty:  0.00641301
p_int:  0.999983267
p_ni:  0.000016733
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
APLF
Tbio
Novelty:  0.01347476
p_int:  0.999982116
p_ni:  0.000017884
Score:  0.78
Data Source:  BioPlex,STRINGDB
RAD23B
Tbio
Novelty:  0.00672104
p_int:  0.999961609
p_ni:  0.000038391
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.999949408
p_ni:  0.000050592
Score:  0.981
Data Source:  BioPlex,STRINGDB
RPA2
Tbio
Novelty:  0.00879115
p_int:  0.99993215
p_ni:  0.00006785
Score:  0.984
Data Source:  BioPlex,STRINGDB
RNF146
Tbio
Family:  Enzyme
Novelty:  0.05463359
p_int:  0.999892263
p_ni:  0.000107737
Score:  0.815
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
DNA Damage Recognition in GG-NER (R-HSA-5696394)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Formation of Incision Complex in GG-NER
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DNA Damage Recognition in GG-NER
DNA Repair
Formation of Incision Complex in GG-NER
Global Genome Nucleotide Excision Repair (GG-NER)
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
57.1
IGF-1 measurement
1
1
1
47.7
heel bone mineral density
1
1
1
30.2
BMI-adjusted hip circumference
1
1
1
21.5
longevity
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
57.1
IGF-1 measurement
1
47.7
heel bone mineral density
1
30.2
BMI-adjusted hip circumference
1
21.5
longevity
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
XPC complex subunit, DNA damage recognition and repair factor
VGNC:10474
460195
Macaque
XPC complex subunit, DNA damage recognition and repair factor
700938
Mouse
MGI:103557
22591
Rat
RGD:1305760
312560
Dog
XPC complex subunit, DNA damage recognition and repair factor
VGNC:48456
476521
Species
Name
OMA
EggNOG
Inparanoid
Chimp
XPC complex subunit, DNA damage recognition and repair factor
Macaque
XPC complex subunit, DNA damage recognition and repair factor
Mouse
Rat
Dog
XPC complex subunit, DNA damage recognition and repair factor
Publication Statistics
PubMed Score 131.78
PubMed score by year
PubTator Score 405.20
PubTator score by year
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Related Publications
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PMID
Year
Title