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Tbio
XIRP1
Xin actin-binding repeat-containing protein 1

Protein Summary
Description
Protects actin filaments from depolymerization. The protein encoded by this gene is a striated muscle protein and belongs to the Xin actin-binding repeat-containing protein (XIRP) family. The protein functions to protect actin filaments during depolymerization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340369
  • ENSP00000343140
  • ENSG00000168334
  • ENST00000396251
  • ENSP00000379550
  • ENST00000421646
  • ENSP00000391645

Symbol
  • CMYA1
  • XIN
  • Xin
  • CMYA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
tissue sample
0.64
cell type or tissue
0.55
cell line
0.44
cellular component
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.54   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.54   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
OXNAD1
Tdark
Family:  Enzyme
Novelty:  1.38777329
Score:  0.9
Data Source:  STRINGDB
CAV3
Tbio
Novelty:  0.00190092
Score:  0.751
Data Source:  STRINGDB
CAPN7
Tbio
Novelty:  0.03088521
Score:  0.75
Data Source:  STRINGDB
FLNC
Tbio
Novelty:  0.00463205
Score:  0.737
Data Source:  STRINGDB
MYOM2
Tbio
Novelty:  0.00032062
Score:  0.703
Data Source:  STRINGDB
MYOZ2
Tbio
Novelty:  0.04557513
Score:  0.662
Data Source:  STRINGDB
ACTN2
Tbio
Novelty:  0.00615882
Score:  0.611
Data Source:  STRINGDB
NRAP
Tbio
Novelty:  0.15548332
Score:  0.58
Data Source:  STRINGDB
SUSD5
Tdark
Novelty:  1.0992718
Score:  0.578
Data Source:  STRINGDB
NRIP2
Tdark
Novelty:  0.5598619
Score:  0.558
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
87.3
monocyte percentage of leukocytes
2
2
3
85.9
lymphocyte count
3
1
3
83.2
granulocyte percentage of myeloid white cells
1
1
1
77.1
neutrophil percentage of leukocytes
1
1
1
72
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
87.3
monocyte percentage of leukocytes
3
85.9
lymphocyte count
3
83.2
granulocyte percentage of myeloid white cells
1
77.1
neutrophil percentage of leukocytes
1
72
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
xin actin binding repeat containing 1
694199
Mouse
MGI:1333878
22437
Dog
xin actin binding repeat containing 1
VGNC:52911
485597
Horse
xin actin binding repeat containing 1
100055451
Cow
xin actin binding repeat containing 1
VGNC:36985
509670
Species
Name
OMA
EggNOG
Inparanoid
Macaque
xin actin binding repeat containing 1
Mouse
Dog
xin actin binding repeat containing 1
Horse
xin actin binding repeat containing 1
Cow
xin actin binding repeat containing 1
Publication Statistics
PubMed Score 21.54
PubMed score by year
PubTator Score 292.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title