You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
XIAP
E3 ubiquitin-protein ligase XIAP

Protein Summary
Description
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355640
  • ENSP00000347858
  • ENSG00000101966
  • ENST00000371199
  • ENSP00000360242
  • ENST00000434753
  • ENSP00000395230

Symbol
  • API3
  • BIRC4
  • IAP3
  • API3
  • ILP1
  • MIHA
  • XLP2
  • BIRC4
  • IAP-3
  • hIAP3
  • hIAP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological process
0.91
microRNA
0.85
cell type or tissue
0.83
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1852.83   (req: < 5)
Gene RIFs: 389   (req: <= 3)
Antibodies: 652   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1852.83   (req: >= 5)
Gene RIFs: 389   (req: > 3)
Antibodies: 652   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 915
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0