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Tbio
XAGE2
X antigen family member 2

Protein Summary
Description
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis, and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286049
  • ENSP00000286049
  • ENSG00000155622

Symbol
  • GAGED3
  • XAGE2B
  • CT12.2
  • GAGED3
  • XAGE-2
  • XAGE2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.58
cellular component
0.52
cell line
0.39
disease
0.27
transcription factor
0.25


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.49   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.49   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
WIZ
Tbio
Family:  TF
Novelty:  0.04458547
p_int:  0.999999965
p_ni:  3.5e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
EHMT2
Tchem
Family:  Epigenetic
Novelty:  0.00262578
p_int:  0.999999554
p_ni:  4.23e-7
p_wrong:  2.3e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
ZNF644
Tbio
Family:  TF
Novelty:  0.12816167
p_int:  0.999999478
p_ni:  5.22e-7
Score:  0.171
Data Source:  BioPlex,STRINGDB
EHMT1
Tchem
Family:  Epigenetic
Novelty:  0.00821799
p_int:  0.999998453
p_ni:  0.000001547
Score:  0.187
Data Source:  BioPlex,STRINGDB
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.999067323
p_ni:  0.00093267
p_wrong:  7e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
CBX5
Tbio
Family:  Epigenetic
Novelty:  0.00653413
p_int:  0.902748666
p_ni:  0.097251333
Score:  0.16
Data Source:  BioPlex,STRINGDB
XAGE1A
Tbio
Novelty:  0.04421526
Score:  0.907
Data Source:  STRINGDB
FOXP4
Tbio
Family:  TF
Novelty:  0.02668451
Score:  0.723
Data Source:  STRINGDB
SPANXD
Tdark
Novelty:  0.22064161
Score:  0.641
Data Source:  STRINGDB
SPANXC
Tbio
Novelty:  0.14907666
Score:  0.587
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 7.49
PubMed score by year
PubTator Score 0.87
PubTator score by year
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Related Publications
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PMID
Year
Title