Tbio WWTR1 WW domain-containing transcription regulator protein 1

Protein Summary

Description

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Uniprot Accession IDs

• Q9GZV5
• D3DNH7
• Q8N3P2
• Q9Y3W6

Gene Name

• WWTR1

Ensembl ID

• ENST00000360632
• ENSP00000353847
• ENSG00000018408
• ENST00000465804
• ENSP00000419465
• ENST00000467467
• ENSP00000419234

Symbol

• TAZ
• TAZ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
PubMedID	0.95
disease perturbation	0.93
kinase perturbation	0.93
transcription factor perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Ww Domain-containing Transcription Regulator Protein 1

Protein / Enzyme Modulator / Kinase Modulator / Ww Domain-containing Transcription Regulator Protein 1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Ww Domain-containing Transcription Regulator Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.63   (req: < 5)

Gene RIFs: 365   (req: <= 3)

Antibodies: 302   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.63   (req: >= 5)

Gene RIFs: 365   (req: > 3)

Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0