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Tbio
WWOX
WW domain-containing oxidoreductase

Protein Summary
Description
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355860
  • ENSP00000348119
  • ENSG00000186153
  • ENST00000402655
  • ENSP00000384238
  • ENST00000406884
  • ENSP00000384495
  • ENST00000408984
  • ENSP00000386161
  • ENST00000566780
  • ENSP00000457230
  • ENST00000569818
  • ENSP00000454485

Symbol
  • FOR
  • SDR41C1
  • WOX1
  • FOR
  • WOX1
  • EIEE28
  • FRA16D
  • SCAR12
  • HHCMA56
  • PRO0128
  • SDR41C1
  • D16S432E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor binding site profile
0.96
transcription factor perturbation
0.96
biological term
0.89
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 444.96   (req: < 5)
Gene RIFs: 196   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 444.96   (req: >= 5)
Gene RIFs: 196   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0