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Tbio
WWOX
WW domain-containing oxidoreductase

Protein Summary
Description
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355860
  • ENSP00000348119
  • ENSG00000186153
  • ENST00000402655
  • ENSP00000384238
  • ENST00000406884
  • ENSP00000384495
  • ENST00000408984
  • ENSP00000386161
  • ENST00000566780
  • ENSP00000457230
  • ENST00000569818
  • ENSP00000454485

Symbol
  • FOR
  • SDR41C1
  • WOX1
  • FOR
  • WOX1
  • EIEE28
  • FRA16D
  • SCAR12
  • HHCMA56
  • PRO0128
  • SDR41C1
  • D16S432E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor binding site profile
0.96
transcription factor perturbation
0.96
biological term
0.89
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 394.61   (req: < 5)
Gene RIFs: 196   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 394.61   (req: >= 5)
Gene RIFs: 196   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.533
Data Source:  BioPlex,STRINGDB
FKBP15
Tbio
Novelty:  0.0570695
p_int:  0.999998116
p_ni:  0.000001884
Score:  0.167
Data Source:  BioPlex,STRINGDB
SERPINA5
Tbio
Family:  Enzyme
Novelty:  0.00152504
p_int:  0.99997832
p_ni:  0.00002168
Score:  0.172
Data Source:  BioPlex,STRINGDB
ARRDC3
Tbio
Novelty:  0.04840692
p_int:  0.999977111
p_ni:  0.000022889
Score:  0.166
Data Source:  BioPlex,STRINGDB
WBP1
Tbio
Novelty:  1.24967974
p_int:  0.999974143
p_ni:  0.000025857
Score:  0.424
Data Source:  BioPlex,STRINGDB
TMEM171
Tdark
Novelty:  2.00247773
p_int:  0.999971158
p_ni:  0.000028842
Data Source:  BioPlex
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
p_int:  0.999945528
p_ni:  0.000054472
Data Source:  BioPlex
DVL2
Tbio
Novelty:  0.00833084
p_int:  0.999909904
p_ni:  0.000090095
p_wrong:  1e-9
Score:  0.689
Data Source:  BioPlex,STRINGDB
TMEM92
Tdark
Novelty:  0.72258983
p_int:  0.999909042
p_ni:  0.000090958
Score:  0.177
Data Source:  BioPlex,STRINGDB
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.999877033
p_ni:  0.000122967
Score:  0.2
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Reactome
Nuclear signaling by ERBB4
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
Gene expression (Transcription)
Generic Transcription Pathway
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Nuclear signaling by ERBB4
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
83.6
forced expiratory volume
1
1
1
70
vital capacity
2
2
1
16.3
67.5
platelet count
1
1
1
64.4
hemoglobin measurement
2
1
2
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
83.6
forced expiratory volume
1
70
vital capacity
1
16.3
67.5
platelet count
1
64.4
hemoglobin measurement
2
64
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WW domain containing oxidoreductase
VGNC:13810
737907
Macaque
WW domain containing oxidoreductase
715635
Mouse
MGI:1931237
80707
Dog
WW domain containing oxidoreductase
VGNC:48442
610120
Cow
WW domain containing oxidoreductase
VGNC:36977
618792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WW domain containing oxidoreductase
Macaque
WW domain containing oxidoreductase
Mouse
Dog
WW domain containing oxidoreductase
Cow
WW domain containing oxidoreductase
Publication Statistics
PubMed Score 394.61
PubMed score by year
PubTator Score 232.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title