Protein Summary
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
- ENST00000265293
- ENSP00000265293
- ENSG00000113645
- ENST00000521089
- ENSP00000427772
- KIAA0869
- KIBRA
- HBEBP3
- HBEBP36
- MEMRYQTL
- PPP1R168
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.94 | ||
kinase | 0.91 | ||
disease perturbation | 0.9 | ||
biological process | 0.81 | ||
kinase perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.56 (req: < 5)
Gene RIFs: 79 (req: <= 3)
Antibodies: 178 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.56 (req: >= 5)
Gene RIFs: 79 (req: > 3)
Antibodies: 178 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (92)
PARD6B
Novelty: 0.08495161
p_int: 0.999999698
p_ni: 2.68e-7
p_wrong: 3.4e-8
Score: 0.852
Data Source: BioPlex,STRINGDB
CDKN3
Family: Enzyme
Novelty: 0.00093913
p_int: 0.999996482
p_ni: 0.000003227
p_wrong: 2.9e-7
Data Source: BioPlex
RHPN1
Novelty: 0.05722992
p_int: 0.999983028
p_ni: 0.00001691
p_wrong: 6.2e-8
Score: 0.299
Data Source: BioPlex,STRINGDB
ARRDC1
Novelty: 0.10481621
p_int: 0.99989359
p_ni: 0.000105861
p_wrong: 5.49e-7
Score: 0.384
Data Source: BioPlex,STRINGDB
PRKCZ
Family: Kinase
Novelty: 0.00201366
p_int: 0.997932395
p_ni: 0.000026397
p_wrong: 0.002041208
Score: 0.979
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (5)
KEGG (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | NOTCH3 Intracellular Domain Regulates Transcription | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Hippo | ||||
Reactome | Signaling by NOTCH | ||||
Reactome | Signaling by NOTCH3 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
NOTCH3 Intracellular Domain Regulates Transcription | ||||
Signal Transduction | ||||
Signaling by Hippo | ||||
Signaling by NOTCH | ||||
Signaling by NOTCH3 | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (3)
Components (6)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
lifestyle measurement | 1 | 1 | 1 | 29 | |||||
smoking initiation | 1 | 1 | 1 | 24.5 | |||||
body height | 1 | 1 | 1 | 21.5 | |||||
health study participation | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
lifestyle measurement | 1 | 29 | |||||
smoking initiation | 1 | 24.5 | |||||
body height | 1 | 21.5 | |||||
health study participation | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | WW and C2 domain containing 1 | VGNC:4226 | 471729 | |||||
Macaque | WW and C2 domain containing 1 | 698875 | ||||||
Mouse | MGI:2388637 | 211652 | ||||||
Rat | RGD:1308329 | 303039 | ||||||
Dog | WW and C2 domain containing 1 | VGNC:48439 | 479297 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | WW and C2 domain containing 1 | |||||
Macaque | WW and C2 domain containing 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | WW and C2 domain containing 1 | |||||
Publication Statistics
PubMed Score 137.56
PubMed score by year
PubTator Score 74.18
PubTator score by year
Related Publications
Text Mined References (90)
GeneRif Annotations (79)
Items per page:
0 of 0
PMID | Year | Title |
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