Tbio WWC1 Protein KIBRA

Protein Summary

Description

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q8IX03
• B4DK05
• O94946
• Q6MZX4
• Q6Y2F8
• Q7Z4G8
• Q8WVM4
• Q9BT29

Gene Name

• WWC1

Ensembl ID

• ENST00000265293
• ENSP00000265293
• ENSG00000113645
• ENST00000521089
• ENSP00000427772

Symbol

• KIAA0869
• KIBRA
• HBEBP3
• HBEBP36
• MEMRYQTL
• PPP1R168

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
kinase	0.91
disease perturbation	0.9
biological process	0.81
kinase perturbation	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.56   (req: < 5)

Gene RIFs: 79   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.56   (req: >= 5)

Gene RIFs: 79   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (92)

Explore Interacting Targets

1 – 10 of 92

• See Interactions on String-DB

PARD6B

Tbio

Novelty:  0.08495161

p_int:  0.999999698

p_ni:  2.68e-7

p_wrong:  3.4e-8

Score:  0.852

Data Source:  BioPlex,STRINGDB

CDKN3

Tbio

Family:  Enzyme

Novelty:  0.00093913

p_int:  0.999996482

p_ni:  0.000003227

p_wrong:  2.9e-7

Data Source:  BioPlex

RHPN1

Tbio

Novelty:  0.05722992

p_int:  0.999983028

p_ni:  0.00001691

p_wrong:  6.2e-8

Score:  0.299

Data Source:  BioPlex,STRINGDB

ARRDC1

Tbio

Novelty:  0.10481621

p_int:  0.99989359

p_ni:  0.000105861

p_wrong:  5.49e-7

Score:  0.384

Data Source:  BioPlex,STRINGDB

PRKCZ

Tchem

Family:  Kinase

Novelty:  0.00201366

p_int:  0.997932395

p_ni:  0.000026397

p_wrong:  0.002041208

Score:  0.979

Data Source:  BioPlex,STRINGDB

LATS2

Tchem

Family:  Kinase

Novelty:  0.00521035

Score:  0.991

Data Source:  Reactome,STRINGDB

LATS1

Tchem

Family:  Kinase

Novelty:  0.00369058

Score:  0.989

Data Source:  Reactome,STRINGDB

KIAA0513

Tdark

Novelty:  0.41452062

Score:  0.985

Data Source:  STRINGDB

NF2

Tbio

Novelty:  0.00055092

Score:  0.965

Data Source:  STRINGDB

FRMD6

Tbio

Novelty:  0.0034642

Score:  0.957

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (5)

KEGG (2)

WikiPathways (2)

NOTCH3 Intracellular Domain Regulates Transcription (R-HSA-9013508)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	NOTCH3 Intracellular Domain Regulates Transcription	25 targets	R-HSA-9013508
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by Hippo	20 targets	R-HSA-2028269
Reactome	Signaling by NOTCH	205 targets	R-HSA-157118
Reactome	Signaling by NOTCH3	49 targets	R-HSA-9012852

Name	Explore in Pharos	Explore in Source
NOTCH3 Intracellular Domain Regulates Transcription	25 targets	R-HSA-9013508
Signal Transduction	2704 targets	R-HSA-162582
Signaling by Hippo	20 targets	R-HSA-2028269
Signaling by NOTCH	205 targets	R-HSA-157118
Signaling by NOTCH3	49 targets	R-HSA-9012852

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (3)

Components (6)

Processes (10)

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GO Term	Evidence	Assigned by
protein-containing complex scaffold activity	Inferred from Direct Assay (IDA)	BHF-UCL
transcription coactivator activity	Inferred from Direct Assay (IDA)	UniProtKB
kinase binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (4)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lifestyle measurement	EFO_0010724	1	1	1		29
smoking initiation	EFO_0005670	1	1	1		24.5
body height	EFO_0004339	1	1	1		21.5
health study participation	EFO_0010130	1	1	1		17.8

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lifestyle measurement	EFO_0010724	1		29
smoking initiation	EFO_0005670	1		24.5
body height	EFO_0004339	1		21.5
health study participation	EFO_0010130	1		17.8

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UniProt Keyword Find Similar Targets

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3D-structure
Activator
Alternative splicing
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Membrane
Nucleus

GWAS Trait Find Similar Targets

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body height
health study participation
lifestyle measurement
smoking initiation

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	WW and C2 domain containing 1	VGNC:4226	471729
Macaque	WW and C2 domain containing 1		698875
Mouse	WW, C2 and coiled-coil domain containing 1	MGI:2388637	211652
Rat	WW and C2 domain containing 1	RGD:1308329	303039
Dog	WW and C2 domain containing 1	VGNC:48439	479297

Species	Name	OMA	EggNOG	Inparanoid
Chimp	WW and C2 domain containing 1
Macaque	WW and C2 domain containing 1
Mouse	WW, C2 and coiled-coil domain containing 1
Rat	WW and C2 domain containing 1
Dog	WW and C2 domain containing 1

Publication Statistics

PubMed Score 137.56

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PubTator Score 74.18

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Related Publications

Text Mined References (90)

GeneRif Annotations (79)

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PMID	Year	Title