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Tbio
WWC1
Protein KIBRA

Protein Summary
Description
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265293
  • ENSP00000265293
  • ENSG00000113645
  • ENST00000521089
  • ENSP00000427772

Symbol
  • KIAA0869
  • KIBRA
  • HBEBP3
  • HBEBP36
  • MEMRYQTL
  • PPP1R168
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase
0.91
disease perturbation
0.9
biological process
0.81
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.56   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.56   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
PARD6B
Tbio
Novelty:  0.08495161
p_int:  0.999999698
p_ni:  2.68e-7
p_wrong:  3.4e-8
Score:  0.852
Data Source:  BioPlex,STRINGDB
CDKN3
Tbio
Family:  Enzyme
Novelty:  0.00093913
p_int:  0.999996482
p_ni:  0.000003227
p_wrong:  2.9e-7
Data Source:  BioPlex
RHPN1
Tbio
Novelty:  0.05722992
p_int:  0.999983028
p_ni:  0.00001691
p_wrong:  6.2e-8
Score:  0.299
Data Source:  BioPlex,STRINGDB
ARRDC1
Tbio
Novelty:  0.10481621
p_int:  0.99989359
p_ni:  0.000105861
p_wrong:  5.49e-7
Score:  0.384
Data Source:  BioPlex,STRINGDB
PRKCZ
Tchem
Family:  Kinase
Novelty:  0.00201366
p_int:  0.997932395
p_ni:  0.000026397
p_wrong:  0.002041208
Score:  0.979
Data Source:  BioPlex,STRINGDB
LATS2
Tchem
Family:  Kinase
Novelty:  0.00521035
Score:  0.991
Data Source:  Reactome,STRINGDB
LATS1
Tchem
Family:  Kinase
Novelty:  0.00369058
Score:  0.989
Data Source:  Reactome,STRINGDB
KIAA0513
Tdark
Novelty:  0.41452062
Score:  0.985
Data Source:  STRINGDB
NF2
Tbio
Novelty:  0.00055092
Score:  0.965
Data Source:  STRINGDB
FRMD6
Tbio
Novelty:  0.0034642
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
NOTCH3 Intracellular Domain Regulates Transcription (R-HSA-9013508)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
NOTCH3 Intracellular Domain Regulates Transcription
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Reactome
Signaling by NOTCH
Reactome
Signaling by NOTCH3
Name
Explore in Pharos
Explore in Source
NOTCH3 Intracellular Domain Regulates Transcription
Signal Transduction
Signaling by Hippo
Signaling by NOTCH
Signaling by NOTCH3
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
1
1
29
smoking initiation
1
1
1
24.5
body height
1
1
1
21.5
health study participation
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
29
smoking initiation
1
24.5
body height
1
21.5
health study participation
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WW and C2 domain containing 1
VGNC:4226
471729
Macaque
WW and C2 domain containing 1
698875
Mouse
MGI:2388637
211652
Rat
RGD:1308329
303039
Dog
WW and C2 domain containing 1
VGNC:48439
479297
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WW and C2 domain containing 1
Macaque
WW and C2 domain containing 1
Mouse
Rat
Dog
WW and C2 domain containing 1
Publication Statistics
PubMed Score 137.56
PubMed score by year
PubTator Score 74.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title