Tbio WTIP Wilms tumor protein 1-interacting protein

Protein Summary

Description

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).

Uniprot Accession IDs

• A6NIX2
• WT1-interacting protein

Gene Name

• WTIP

Ensembl ID

• ENST00000590071
• ENSP00000466953
• ENSG00000142279

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.74
cellular component	0.64
cell type or tissue	0.61
histone modification site profile	0.59
tissue sample	0.59

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Wilms Tumor Protein 1-interacting Protein

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Wilms Tumor Protein 1-interacting Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.06   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.06   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0