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Tbio
WT1
Wilms tumor protein

Protein Summary
Description
Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379079
  • ENSP00000368370
  • ENSG00000184937
  • ENST00000530998
  • ENSP00000435307

Symbol
  • GUD
  • AWT1
  • WAGR
  • WT33
  • NPHS4
  • WIT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.98
phenotype
0.86
molecular function
0.84
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3174.82   (req: < 5)
Gene RIFs: 525   (req: <= 3)
Antibodies: 1029   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3174.82   (req: >= 5)
Gene RIFs: 525   (req: > 3)
Antibodies: 1029   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (265)
PAX2
Tbio
Family:  TF
Novelty:  0.00160808
Score:  0.966
Data Source:  STRINGDB
TP73
Tbio
Family:  TF
Novelty:  0.00667737
Score:  0.957
Data Source:  STRINGDB
TERT
Tchem
Family:  Enzyme
Novelty:  0.00024411
Score:  0.945
Data Source:  STRINGDB
DNAJA3
Tbio
Novelty:  0.02196177
Score:  0.901
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.895
Data Source:  STRINGDB
NPHS1
Tbio
Novelty:  0.00104742
Score:  0.892
Data Source:  STRINGDB
CITED2
Tbio
Novelty:  0.01028104
Score:  0.865
Data Source:  STRINGDB
SOX9
Tbio
Family:  TF
Novelty:  0.00047439
Score:  0.852
Data Source:  STRINGDB
TCF21
Tbio
Family:  TF
Novelty:  0.0005831
Score:  0.846
Data Source:  STRINGDB
WNT4
Tbio
Novelty:  0.00276803
Score:  0.843
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (67)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
79.3
Inguinal hernia
1
1
0
1.1
60.5
mean corpuscular volume
1
1
1
52.4
1
1
0
1.1
48.5
mean reticulocyte volume
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
79.3
Inguinal hernia
0
1.1
60.5
mean corpuscular volume
1
52.4
0
1.1
48.5
mean reticulocyte volume
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wilms tumor 1
737987
Macaque
Wilms tumor 1
696061
Mouse
MGI:98968
22431
Rat
RGD:3974
24883
Dog
Wilms tumor 1
VGNC:48438
609253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wilms tumor 1
Macaque
Wilms tumor 1
Mouse
Rat
Dog
Wilms tumor 1
Publication Statistics
PubMed Score 3174.82
PubMed score by year
PubTator Score 1898.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title