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Tbio
WSB1
WD repeat and SOCS box-containing protein 1

Protein Summary
Description
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262394
  • ENSP00000262394
  • ENSG00000109046
  • ENST00000348811
  • ENSP00000327055

Symbol
  • SWIP1
  • SWIP1
  • WSB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.94
transcription factor binding site profile
0.91
protein domain
0.85
virus perturbation
0.83
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.82   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.82   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (332)
CUL5
Tbio
Novelty:  0.00792494
p_int:  1
Score:  0.953
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.99999999
p_ni:  2e-9
p_wrong:  8e-9
Score:  0.914
Data Source:  BioPlex,STRINGDB
SIAH2
Tbio
Family:  Enzyme
Novelty:  0.01461174
Score:  0.959
Data Source:  STRINGDB
SIAH1
Tbio
Family:  Enzyme
Novelty:  0.00831224
Score:  0.956
Data Source:  STRINGDB
CISH
Tbio
Novelty:  0.00145893
Score:  0.952
Data Source:  STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.952
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.95
Data Source:  STRINGDB
LRRC41
Tbio
Novelty:  0.12601472
Score:  0.949
Data Source:  STRINGDB
FBXW8
Tbio
Novelty:  0.06697145
Score:  0.944
Data Source:  STRINGDB
SPSB4
Tdark
Novelty:  0.07251424
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
10.7
birth weight
1
1
1
10.1
body height
1
1
1
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
10.7
birth weight
1
10.1
body height
1
2.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WD repeat and SOCS box containing 1
706172
Mouse
MGI:1926139
78889
Rat
RGD:1307835
303336
Dog
WD repeat and SOCS box containing 1
VGNC:48435
480619
Horse
WD repeat and SOCS box containing 1
VGNC:25055
100058727
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WD repeat and SOCS box containing 1
Mouse
Rat
Dog
WD repeat and SOCS box containing 1
Horse
WD repeat and SOCS box containing 1
Publication Statistics
PubMed Score 25.82
PubMed score by year
PubTator Score 11.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title