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Tbio
WRB
Tail-anchored protein insertion receptor WRB

Protein Summary
Description
Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane. This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333781
  • ENSP00000327716
  • ENSG00000182093
  • ENST00000380708
  • ENSP00000370084
  • ENST00000398753
  • ENSP00000381737
  • ENST00000649170
  • ENSP00000496813
  • ENST00000650376
  • ENSP00000497103

Symbol
  • CHD5
  • CHD5
  • GET1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.76
disease perturbation
0.74
tissue sample
0.72
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.79   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.79   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
ASNA1
Tbio
Family:  Enzyme
Novelty:  0.01260233
p_int:  0.999498812
p_ni:  0.000501188
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.961954509
p_ni:  0.038045422
p_wrong:  7e-8
Data Source:  BioPlex
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.905364207
p_ni:  0.0946352
p_wrong:  5.92e-7
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.864592532
p_ni:  0.135407468
Data Source:  BioPlex
ITGB8
Tbio
Novelty:  0.01564348
p_int:  0.858312923
p_ni:  0.141582575
p_wrong:  0.000104502
Score:  0.314
Data Source:  BioPlex,STRINGDB
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.814310328
p_ni:  0.185647052
p_wrong:  0.00004262
Score:  0.161
Data Source:  BioPlex,STRINGDB
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.804905351
p_ni:  0.195093236
p_wrong:  0.000001414
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.801673689
p_ni:  0.198325667
p_wrong:  6.44e-7
Data Source:  BioPlex
TLR1
Tbio
Novelty:  0.00171909
p_int:  0.796880934
p_ni:  0.202619806
p_wrong:  0.00049926
Data Source:  BioPlex
CAMLG
Tbio
Novelty:  0.0088918
Score:  0.909
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
4
9
92.9
Non-accomodative esotropia
1
1
0
1.4
61.3
apolipoprotein B measurement
1
1
1
56.8
antisocial behaviour measurement
1
1
1
55.3
1
1
1
55.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
92.9
Non-accomodative esotropia
0
1.4
61.3
apolipoprotein B measurement
1
56.8
antisocial behaviour measurement
1
55.3
1
55.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tryptophan rich basic protein
VGNC:1112
100611690
Macaque
tryptophan rich basic protein
106997239
Mouse
MGI:2136882
71446
Rat
RGD:735104
288233
Horse
tryptophan rich basic protein
VGNC:25054
100059393
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tryptophan rich basic protein
Macaque
tryptophan rich basic protein
Mouse
Rat
Horse
tryptophan rich basic protein
Publication Statistics
PubMed Score 103.79
PubMed score by year
PubTator Score 79.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title