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Tbio
WRAP73
WD repeat-containing protein WRAP73

Protein Summary
Description
The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238). This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270708
  • ENSP00000270708
  • ENSG00000116213

Symbol
  • WDR8
  • WDR8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
histone modification site profile
0.72
tissue
0.61
tissue sample
0.6
cell type or tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.86   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.86   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
HDDC3
Tbio
Family:  Enzyme
Novelty:  0.03421685
p_int:  1
Score:  0.277
Data Source:  BioPlex,STRINGDB
CEP135
Tbio
Novelty:  0.03507768
p_int:  0.999999837
p_ni:  1.63e-7
Score:  0.894
Data Source:  BioPlex,STRINGDB
SSX2IP
Tbio
Novelty:  0.01381625
p_int:  0.999999706
p_ni:  2.93e-7
Score:  0.75
Data Source:  BioPlex,STRINGDB
ZBTB44
Tdark
Family:  TF
Novelty:  0.75195191
p_int:  0.999998524
p_ni:  1.12e-7
p_wrong:  0.000001364
Score:  0.185
Data Source:  BioPlex,STRINGDB
SPEN
Tbio
Novelty:  0.01211011
p_int:  0.999976983
p_ni:  0.000023017
Score:  0.159
Data Source:  BioPlex,STRINGDB
QRICH1
Tdark
Novelty:  0.27714699
p_int:  0.999792363
p_ni:  0.000207634
p_wrong:  2e-9
Data Source:  BioPlex
CLEC16A
Tbio
Novelty:  0.0212098
p_int:  0.999683475
p_ni:  0.000204864
p_wrong:  0.000111661
Score:  0.222
Data Source:  BioPlex,STRINGDB
TNKS1BP1
Tbio
Family:  Enzyme
Novelty:  0.21682007
p_int:  0.998176093
p_ni:  0.001823907
Data Source:  BioPlex
OSBPL9
Tbio
Novelty:  0.07633459
p_int:  0.997186749
p_ni:  0.002813243
p_wrong:  8e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
SDCBP
Tbio
Novelty:  0.00242211
p_int:  0.993808405
p_ni:  0.006191595
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat containing, antisense to TP73
VGNC:10388
457233
Macaque
WD repeat containing, antisense to TP73
695276
Mouse
MGI:1891749
59002
Dog
WD repeat containing, antisense to TP73
VGNC:48433
479584
Horse
WD repeat containing, antisense to TP73
VGNC:25053
100060634
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat containing, antisense to TP73
Macaque
WD repeat containing, antisense to TP73
Mouse
Dog
WD repeat containing, antisense to TP73
Horse
WD repeat containing, antisense to TP73
Publication Statistics
PubMed Score 7.86
PubMed score by year
PubTator Score 3.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title